Publications by authors named "Kevin Gonthier"
Article Synopsis
- Scientists studied the estrogen receptor α (ERα) in prostate cancer and found it only appears in about half of the patients' tumors.
- When ERα is present, it can affect how the cancer grows and spreads, and is linked to patients' chances of survival.
- The research suggests that targeting ERα could be a new way to treat prostate cancer by changing how cancer cells use energy.
The androgen receptor (AR) is an established orchestrator of cell metabolism in prostate cancer (PCa), notably by inducing an oxidative mitochondrial program. Intriguingly, AR regulates cytoplasmic isocitrate dehydrogenase 1 (IDH1), but not its mitochondrial counterparts IDH2 and IDH3. Here, we aimed to understand the functional role of IDH1 in PCa.
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- The prostate produces a special substance called citrate that helps keep males fertile, but in prostate cancer, this process changes and is tricky to understand.!
- Researchers studied mouse and human prostate cells in the lab to find out how citrate is made and discovered there are at least four different ways the prostate makes citrate, not just the one they thought before.!
- Understanding these processes better could help with treating prostate cancer and improving male fertility in the future.!
Cellular homeostasis requires the orderly expression of thousands of transcripts. Gene expression is regulated by numerous proteins that recognize post-translational modifications-in particular, the acetylation of lysine residues (Kac) on histones. In addition to affecting the general condensation state of the chromatin, acetylated histones act as anchor points for bromodomain (BRD)-containing adapter proteins.
View Article and Find Full Text PDFMutations of the isocitrate dehydrogenase genes and , key enzymes involved in citrate metabolism, are important oncogenic events in several cancer types, including in 1%-3% of all prostate cancer cases. However, if and other IDH isoforms are associated with prostate cancer progression, as well as the regulatory factors controlling their expression and activity, remain mostly unknown. Using publicly available datasets, we showed that prostate cancer harbors the highest expression across the human cancer spectrum and that expression is altered during prostate cancer progression.
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- Scientists have been studying sex-steroid hormones, like androgens, to understand their role in certain types of cancer, especially prostate cancer.
- Androgens help healthy prostate cells grow and develop but can also lead to cancer cells growing out of control.
- New research shows that androgen receptors not only control cell growth but also affect how cancer cells use energy, which is important for tumor growth.