Non-homologous use of adipose-derived cell and tissue therapies: Osteoarthritis as a case study.

Adipose tissue is widely recognized as an abundant and accessible human tissue that serves as a source of cells and extracellular matrix scaffolds for regenerative surgical applications. Increasingly, orthopedic surgeons are turning to adipose tissue as a resource in their treatment of osteoarthritis and related conditions. In the U.

Clinical use of autologous micro-fragmented fat progressively restores pain and function in shoulder osteoarthritis.

We aim to show that the use of nondigested micro-fragmented adipose tissue (MFat™, Lipogems) is a viable alternative for treatment of joint pain and inflammation associated dysfunction in shoulder osteoarthritis (OA).  A total of 25 subjects with OA received an injection of MFat™ and were followed at 6, 18 and 52 weeks intervals. Quantitative analysis of pain and function modalities were performed using the visual analog scale and the disabilities of the arm, shoulder and hand, respectively.