Publications by authors named "Kevin Dueck"
Article Synopsis
- The Vaccinia E3 protein can bind to double-stranded RNA (dsRNA) and is involved in suppressing immune responses and influencing host range.
- Although many mutants of this protein showed impaired dsRNA binding and replication, some retained their ability to function biologically.
- The findings suggest that the E3 protein’s biological functions may operate through a mechanism independent of its dsRNA binding capability.
Background: Defects in tight junctions, gate-keepers of the integrity of the epidermal barrier function, are known to contribute to cancer development. As such, enhancing our understanding of how the expression of proteins involved in these junctions is regulated in cancer, remains a priority. Although the expression of one of these proteins, claudin 1, is down regulated in most invasive human breast cancers (HBC), we have recently shown that high levels of claudin 1, characterized tumors belonging to the very aggressive basal-like breast cancer (BLBC) subtype.
View Article and Find Full Text PDF