Publications by authors named "Kevin D Cravedi"

Preclinical models of organismal response to traumatic stress (threat of death or serious injury) can be monitored using neuroendocrine, behavioral, and structural metrics. While many rodent models of traumatic stress have provided a glimpse into select components of the physiological response to acute and chronic stressors, few studies have directly examined the potential differences between stressors and their potential outcomes. To address this gap, we conducted a multi-level comparison of the immediate and longer-term effects of two types of acute traumatic stressors.

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Article Synopsis
  • Epilepsy, deafness, and other disorders linked to TBC1D24 mutations are not fully understood, prompting researchers to create a mouse model with a specific mutant gene variant associated with early infantile epileptic encephalopathy (EIEE).
  • The engineered mice exhibit normal hearing but develop spontaneous seizures around postnatal day 15, mimicking the human condition, which corresponds with a change in how the TBC1D24 protein is made during development.
  • The study highlights the important role of TBC1D24 in neuronal function and opens the door for testing new medications to treat seizure disorders linked to TBC1D24 mutations.
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