Publications by authors named "Kevin Cory"
Physical activity is associated with beneficial adaptations in human and rodent metabolism. We studied over 50 complex traits before and after exercise intervention in middle-aged men and a panel of 100 diverse strains of female mice. Candidate gene analyses in three brain regions, muscle, liver, heart, and adipose tissue of mice indicate genetic drivers of clinically relevant traits, including volitional exercise volume, muscle metabolism, adiposity, and hepatic lipids.
View Article and Find Full Text PDFObjective: As appointments become more rushed, it is crucial that primary care clinicians consider new and effective ways to provide preventive health education to patients. Currently, patient education is often handouts printed from the electronic medical record system; however, these pieces of paper often do not have the desired impact. Well-established advertising methods reveal that repeated exposure is key in recall and swaying consumer decisions.
View Article and Find Full Text PDFArticle Synopsis
- - Mitochondrial dysfunction is linked to metabolic issues and insulin resistance, but it's uncertain if it causes or results from these problems in humans.
- - Researchers studied "mutator" mice (PolG), which accumulate many mitochondrial DNA mutations without showing signs of accelerated aging, to understand the effects on metabolism and insulin action.
- - Despite the high level of mtDNA mutations, the study found no significant differences in metabolism or insulin action between the mutator mice and normal mice, suggesting that these mutations alone don't disrupt metabolic balance in male mice.
Duchenne muscular dystrophy (DMD) is characterized by rapid wasting of skeletal muscle. Mitochondrial dysfunction is a well-known pathological feature of DMD. However, whether mitochondrial dysfunction occurs before muscle fiber damage in DMD pathology is not well known.
View Article and Find Full Text PDFObjective: Mitochondria are organelles primarily responsible for energy production, and recent evidence indicates that alterations in size, shape, location, and quantity occur in response to fluctuations in energy supply and demand. We tested the impact of acute and chronic exercise on mitochondrial dynamics signaling and determined the impact of the mitochondrial fission regulator Dynamin related protein (Drp)1 on exercise performance and muscle adaptations to training.
Methods: Wildtype and muscle-specific Drp1 heterozygote (mDrp1) mice, as well as dysglycemic (DG) and healthy normoglycemic men (control) performed acute and chronic exercise.