Publications by authors named "Kevin Colon-Negron"
Background: Myriad challenges to the proper folding and structural maturation of secretory pathway client proteins in the endoplasmic reticulum (ER) - a condition referred to as "ER stress" - activate intracellular signaling pathways termed the unfolded protein response (UPR).
Scope Of Review: Through executing transcriptional and translational programs the UPR restores homeostasis in those cells experiencing manageable levels of ER stress. But the UPR also actively triggers cell degeneration and apoptosis in those cells that are encountering ER stress levels that exceed irremediable thresholds.
Article Synopsis
- * ABL family tyrosine kinases enhance the activity of IRE1α, increasing the likelihood of apoptosis in stressed cells, while the anti-cancer drug imatinib can inhibit this interaction, potentially reducing cell death.
- * Research shows that targeting the ABL-IRE1α relationship with drugs like imatinib or other inhibitors could help reverse type 1 diabetes in mice by protecting β cells and improving their function.