Publications by authors named "Kevin Charland"
Article Synopsis
- Incorporating broad genetic diversity in disease modeling can improve its relevance to human diseases, as inbred mouse strains often fail to accurately reflect these conditions.
- A new cross-species precision disease modeling platform has been developed, utilizing the genetic diversity of mice to connect cellular and organism-level studies.
- The study found that differences in genetic backgrounds influenced the effects of neurodevelopmental gene mutations, revealing key molecular pathways that affect resilience or sensitivity to these changes.
Introduction: In September 2022, The Jackson Laboratory Center for Alzheimer's and Dementia Research (JAX CADR) hosted a workshop with leading researchers in the Alzheimer's disease and related dementias (ADRD) field.
Methods: During the workshop, the participants brainstormed new directions to overcome current barriers to providing patients with effective ADRD therapeutics. The participants outlined specific areas of focus.