Publications by authors named "Kevin C Robertson"
Article Synopsis
- * A study utilizing quantitative proteomics and PLK1 inhibition uncovered how extensively PLK1 influences protein breakdown at this stage of the cell cycle, validating numerous regulated proteins.
- * One important finding is that the degradation of A-kinase anchor protein 2 (AKAP2) through PLK1 impacts cytoskeletal organization during mitosis, revealing PLK1's significant role in shaping the proteins involved in cell division, which may relate to cancer when PLK1 levels are increased.
Targeted protein degradation by the ubiquitin-proteasome system is an essential mechanism regulating cellular division. The kinase PLK1 coordinates protein degradation at the G2/M phase of the cell cycle by promoting the binding of substrates to the E3 ubiquitin ligase SCF. However, the magnitude to which PLK1 shapes the mitotic proteome has not been characterized.
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