Publications by authors named "Kevin Busuttil"
Article Synopsis
- - Human alpha-defensin antimicrobial peptides, specifically human neutrophil peptide 1 (HNP1) and human defensin 5 (HD5), significantly inhibit the effectiveness of adeno-associated virus (AAV2) vectors used in gene therapy by blocking infection and preventing the virus from reaching the nucleus.
- - HD5 stops AAV2 from binding to cells, while HNP1 does not, but both defensins interfere with key viral processes that are necessary for the virus's success in infecting cells.
- - These findings suggest a shared mechanism of action among alpha-defensins in neutralizing various non-enveloped viruses, which could lead to advancements in developing more effective gene therapy vectors that can overcome innate immune barriers.
Aims: This study considered the effects of supervised, low volume, high intensity of effort resistance training compared to continued routine care in persons with type II diabetes.
Methods: We utilized a randomized parallel-group time-series design. All participants completed baseline testing (T0) and then participated in an educational training intervention regarding the management of their diabetes and were followed up for six months, during which they received routine care before being retested (T1).