Developmental exposure to legacy environmental contaminants, medial temporal lobe volumes and spatial navigation memory in late adolescents.

Exposure to lead, mercury, and polychlorinated biphenyls (PCBs) has been causally linked to spatial memory deficits and hippocampal changes in animal models. The Inuit community in Northern Canada is exposed to higher concentrations of these contaminants compared to the general population. This study aimed to 1) investigate associations between prenatal and current contaminant exposures and medial temporal brain volumes in Inuit late adolescents; 2) examine the relationship between these brain structures and spatial memory; and 3) assess the mediating role of brain structures in the association between contaminant exposure and spatial memory.

Associations between developmental exposure to environmental contaminants and spatial navigation in late adolescence.

Inuit communities in Northern Quebec (Canada) are exposed to environmental contaminants, particularly to mercury, lead and polychlorinated biphenyls (PCBs). Previous studies reported adverse associations between these neurotoxicants and memory performance. Here we aimed to determine the associations of pre- and postnatal exposures to mercury, lead and PCB-153 on spatial navigation memory in 212 Inuit adolescents (mean age = 18.

Characterizing the Effects of Enchroma Glasses on Color Discrimination.

Significance: Enchroma glasses were designed to improve color vision among color-blind individuals. The putative aid of such optic filters in alleviating color blindness remains to be demonstrated. Our study shows that the beneficial impacts on color discrimination are quite small in comparison to the undesirable effects.

Environmental toxic agents: The impact of heavy metals and organochlorides on brain development.

Exposure to environmental toxicants can have deleterious effects on the development of physical, cognitive, and mental health. Extensive laboratory and clinical studies have demonstrated how the developing brain is uniquely sensitive to toxic agents. This chapter focuses on the main neurologic impairments linked to prenatal and postnatal exposure to lead, methylmercury, and polychlorinated biphenyls, three legacy environmental contaminants whose neurotoxic effects have been extensively studied with respect to cognitive and behavioral development.