Publications by authors named "Kevin Bampoe"
Patients with type II lissencephaly, a neuronal migration disorder with ectopic neurons, suffer from severe mental retardation, including learning deficits. There is no effective therapy to prevent or correct the formation of neuronal ectopia, which is presumed to cause cognitive deficits. We hypothesized that learning deficits were not solely caused by neuronal ectopia and that postnatal gene therapy could improve learning without correcting the neuronal ectopia formed during fetal development.
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- Alloreactive T cells play a critical role in graft-versus-host disease (GVHD), and their movement into affected organs can be altered to reduce disease severity.
- P-selectin, a glycoprotein on blood vessel linings, is significant for the movement of these T cells into GVHD-target organs, as evidenced by lower GVHD-related mortality and symptoms in P-selectin-deficient mice.
- Interestingly, T cells lacking the main P-selectin binding protein behave similarly to normal T cells, suggesting they can use other binding mechanisms, indicating a complex interaction and potential therapeutic target in GVHD management.