Advances in antimicrobial orthopaedic devices and FDA regulatory challenges.

Implant-associated infections, caused by the formation of biofilms especially antibiotic resistant organisms, are among the leading causes of orthopaedic implant failure. Current strategies to combat infection and biofilm focus on either inhibiting bacterial growth or preventing bacterial adherence that could lead to biofilm creation. Despite research on developing numerous antimicrobial orthopaedic devices, to date, no robust solution has been translated to the clinic.

Social Expectation Improves Speech Perception in Noise.

Listeners' use of social information during speech perception was investigated by measuring transcription accuracy of Chinese-accented speech in noise while listeners were presented with a congruent Chinese face, an incongruent Caucasian face, or an uninformative silhouette. When listeners were presented with a Chinese face they transcribed more accurately than when presented with the Caucasian face. This difference existed both for listeners with a relatively high level of experience and for listeners with a relatively low level of experience with Chinese-accented English.

The socially weighted encoding of spoken words: a dual-route approach to speech perception.

Spoken words are highly variable. A single word may never be uttered the same way twice. As listeners, we regularly encounter speakers of different ages, genders, and accents, increasing the amount of variation we face.

Mitigating adverse event reporting bias in spine surgery.

Background: Recent articles in the lay press and literature have raised concerns about the ability to report honest adverse event data from industry-sponsored spine surgery studies. To address this, clinical trials may utilize an independent Clinical Events Committee (CEC) to review adverse events and readjudicate the severity and relatedness accordingly. We are aware of no prior study that has quantified either the degree to which investigator bias is present in adverse event reporting or the effect that an independent CEC has on mitigating this potential bias.

The time course of perception of coarticulation.

The perception of coarticulated speech as it unfolds over time was investigated by monitoring eye movements of participants as they listened to words with oral vowels or with late or early onset of anticipatory vowel nasalization. When listeners heard [CṼNC] and had visual choices of images of CVNC (e.g.

Regulatory Challenges for Cartilage Repair Technologies.

In the United States, few Food and Drug Administration (FDA)-approved options exist for the treatment of focal cartilage and osteochondral lesions. Developers of products for cartilage repair face many challenges to obtain marketing approval from the FDA. The objective of this review is to discuss the necessary steps for FDA application and approval for a new cartilage repair product.

Treatment of cartilage with beta-aminopropionitrile accelerates subsequent collagen maturation and modulates integrative repair.

Integrative repair of cartilage was previously found to depend on collagen synthesis and maturation. beta-aminopropionitrile (BAPN) treatment, which irreversibly blocks lysyl oxidase, inhibited the formation of collagen crosslinks, prevented development of adhesive strength, and caused a buildup of GuHCl-extractable collagen crosslink precursors. This buildup of crosslink precursor in the tissue may be useful for enhancing integrative repair.

Inhibition of integrative cartilage repair by proteoglycan 4 in synovial fluid.

Objective: To determine the effects of the articular cartilage surface, as well as synovial fluid (SF) and its components, specifically proteoglycan 4 (PRG4) and hyaluronic acid (HA), on integrative cartilage repair in vitro.

Methods: Blocks of calf articular cartilage were harvested, some with the articular surface intact and others without. Some of the latter types of blocks were pretreated with trypsin, and then with bovine serum albumin, SF, PRG4, or HA.

Mechanical characterization of native and tissue-engineered cartilage.

Cartilage functions as a low-friction, wear-resistant, load-bearing tissue. During a normal gait cycle, one cartilage surface rolls and slides against another, all the while being loaded and unloaded. The durability of the tissue also makes for an impressive material to study.

A compositional analysis of human nasal septal cartilage.

Background: Nasal septal cartilage is well established as an autograft material. Tissue engineering methods are now being developed to synthesize cartilage constructs with the properties of this type of cartilage. However, important baseline data on the composition of native septal cartilage is sparse.