Publications by Keung Youp Lee

Publications by authors named "Keung Youp Lee"

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Cathepsin B is a target of Hedgehog signaling in pancreatic cancer.

Jin-Hyeok Hwang Sang Hyub Lee Kwang Hyuck Lee Keung Youp Lee Haeryoung Kim

Cancer Lett

January 2009

This study investigated the influence of cathepsin B (CATB), a downstream target of Hedgehog (Hh) signaling, in pancreatic cancer. Cyclopamine (Hh signal inhibitor) suppressed expression of Shh, as well as Hh-induced transcription factor Gli1, and induced apoptosis in Shh-positive pancreatic cancer cell line (PANC-1). Microarray analysis revealed CATB as a gene downregulated by Hh.

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