Publications by authors named "Keun Young Cheon"
Article Synopsis
- MIS/AMH, produced in ovarian granulosa cells, is believed to inhibit ovarian folliculogenesis and steroidogenesis in women of reproductive age.
- The study aimed to investigate the expression of the MISRII/AMHRII receptor in ovarian tissues, using human samples from 25 patients who underwent ovarian surgery and analyzing cell-specific expression via RT-PCR and immunohistochemistry.
- Findings indicated that MISRII/AMHRII is expressed in both granulosa and theca cells, suggesting MIS/AMH may play a role in autocrine, endocrine, and paracrine processes within the ovaries.
The mitochondrial pool of Hsp90 and its mitochondrial paralogue, TRAP1, suppresses cell death and reprograms energy metabolism in cancer cells; therefore, Hsp90 and TRAP1 have been suggested as target proteins for anticancer drug development. Here, we report that the actual target protein in cancer cell mitochondria is TRAP1, and current Hsp90 inhibitors cannot effectively inactivate TRAP1 because of their insufficient accumulation in the mitochondria. To develop mitochondrial TRAP1 inhibitors, we determined the crystal structures of human TRAP1 complexed with Hsp90 inhibitors.
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