Publications by authors named "Keun Park"

Background: Remote ischemic conditioning (RIC) has been implicated in cross-organ protection in cerebrovascular disease, including stroke. However, the lack of a consensus protocol and controversy over the clinical therapeutic outcomes of RIC suggest an inadequate mechanistic understanding of RIC. The current study identifies RIC-induced molecular and cellular events in the blood, which enhance long-term functional recovery in experimental cerebral ischemia.

View Article and Find Full Text PDF

Background And Objectives: The optimal timing for complete revascularization (CR) in patients with acute myocardial infarction (AMI) and multivessel disease (MVD) remain uncertain.

Methods: This post-hoc analysis of the FRAME-AMI trial included AMI patients with MVD ( = 549). They were classified into immediate ( = 329) and staged CR ( = 220) groups.

View Article and Find Full Text PDF

Objective: This study evaluated the effects of increased levels of dietary total digestible nutrient (TDN) and crude protein (CP) using protected fat (PF), soybean meal (SB), and heat-treated soybean meal (HSB) on performance, physiological parameters, and behavioral measurements of early-fattening Hanwoo steers under heat stress conditions.

Methods: Thirty-six steers (480.9±58.

View Article and Find Full Text PDF

Aims: To assess the efficacy and safety of sarpogrelate (300 mg) for symptom improvement in patients having peripheral arterial disease (PAD) and/or being at risk of PAD in clinical practice using the Peripheral Artery Questionnaire (PAQ).

Background: Symptomatic changes with antiplatelets in patients with PAD are limited.

Objective: To determine the effect and safety of sarpogrelate on the PAQ at 24 weeks from baseline.

View Article and Find Full Text PDF

Background: Aneurysmal subarachnoid hemorrhage (aSAH) has an incidence of 6-7 per 100,000 person-years. Despite advancements in treatment, 26% of patients die and 19% remain dependent after hemorrhage. Long-term neuropsychological sequelae affect about half of the survivors, significantly affecting their quality of life.

View Article and Find Full Text PDF
Article Synopsis
  • Preventive treatments for unruptured intracranial aneurysms (UIAs) are commonly used, but their long-term cognitive impacts, particularly concerning dementia, have been underestimated.
  • A study comparing two groups (treatment vs. observation) using National Health Insurance data found that the incidence rates of dementia were similar in both groups, suggesting treatment may not significantly affect cognitive outcomes.
  • Within the treatment group, surgical methods showed a higher dementia risk, especially in male patients, indicating the need for further research to identify patients at higher risk for developing dementia post-treatment.
View Article and Find Full Text PDF

Introduction: Ceramides are essential epidermal constituents that play a critical role in skin moisturization treatment as a raw material in cosmetics formulation. Recently, ceramides have been known to be frequently applied in various cosmetic formulations. Despite ceramide's beneficial characteristics, academic research regarding ceramides and their skin absorption remains insufficient.

View Article and Find Full Text PDF

Background: Detection and localization of cerebral microbleeds (CMBs) is crucial for disease diagnosis and treatment planning. However, CMB detection is labor-intensive, time-consuming, and challenging owing to its visual similarity to mimics. This study aimed to validate the performance of a three-dimensional (3D) deep learning model that not only detects CMBs but also identifies their anatomic location in real-world settings.

View Article and Find Full Text PDF
Article Synopsis
  • Atherogenic dyslipidemia is a condition linked to type 2 diabetes that can cause serious heart problems.
  • Statins are usually the main medicine given to help lower cholesterol, but researchers want to see if combining them with other drugs like ezetimibe and fibrates can work better.
  • In a study with nearly 4,000 people, scientists will compare the effects of adding ezetimibe and fibrates to statins versus just increasing the dose of statins alone, looking for improvements over four years.
View Article and Find Full Text PDF

Background And Objectives: Postclipping cerebral infarction (PCI) remains a major concern after treatment for unruptured intracranial aneurysms (UIAs). However, studies of microsurgical clipping based on diffusion-weighted imaging are limited. We aimed to present the incidence, risk factors, and types of PCI and its radiological and clinical characteristics.

View Article and Find Full Text PDF

Background: Trigeminal nerve injury following endodontic treatment, leading to unpleasant sensations or partial sensory loss in the face or oral mucosa, is uncommon but significant when it occurs.

Objective: This study analysed the pharmacological management of trigeminal nerve injuries (TNI) in a university-based hospital.

Methods: We conducted a retrospective analysis of 47 patients who visited the Department of Orofacial Pain and Oral Medicine at Yonsei University Dental Hospital, Seoul, Korea, after TNI following endodontic procedures in primary clinics.

View Article and Find Full Text PDF

Purpose: This systematic review and meta-analysis aimed to investigate the effectiveness of carbon ion radiotherapy (CIRT) compared to that of conventional radiotherapy in patients with various types of solid tumors.

Materials And Methods: We systematically searched eight electronic databases from inception until August 2022 in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. The comparative effectiveness of the different treatment options was assessed by a random-effects meta-analysis.

View Article and Find Full Text PDF

Background: The Murray law-based quantitative flow ratio (μFR) is an emerging technique that requires only 1 projection of coronary angiography with similar accuracy to quantitative flow ratio (QFR). However, it has not been validated for the evaluation of noninfarct-related artery (non-IRA) in acute myocardial infarction (AMI) settings. Therefore, our study aimed to evaluate the diagnostic accuracy of μFR and the safety of deferring non-IRA lesions with μFR >0.

View Article and Find Full Text PDF

Objective: This study aimed to determine the effects of increasing energy and protein levels in diets by including protected fat (PF), glycerol (GL), and soybean meal (SBM) on growth performance, physiological parameters, carcass characteristics, and behavioral measurements of late-fattening Hanwoo steers under heat stress conditions.

Methods: Thirty-six steers (initial body weight, 724.9±58.

View Article and Find Full Text PDF
Article Synopsis
  • - Tailor-made synthetic sRNA-based gene knockdown systems effectively regulate gene expression in microbes by leveraging competitive interactions with the Hfq protein, which is crucial for RNA stability and function.
  • - A new approach was introduced that modulates Hfq expression levels using various strength promoters to enhance the efficiency of sRNA, leading to improved gene repression capabilities as shown by tests with fluorescent proteins.
  • - Application of this enhanced system in E. coli resulted in significant increases in the production of valuable compounds, specifically a 74.6% boost in 5-aminolevulinic acid and a 144% increase in L-tyrosine, highlighting its potential for optimizing metabolic pathways in biotechnological applications.
View Article and Find Full Text PDF

Schizophyllan (SPG), a β-glucan from Schizophyllum commune, is recognized for its antioxidant, immunoregulatory, and anticancer activities. In this study, its effects on bone cells, particularly osteoclasts and osteoblasts, were examined. We demonstrated that SPG dose-dependently inhibited osteoclastogenesis and reduced gene expression associated with osteoclast differentiation.

View Article and Find Full Text PDF
Article Synopsis
  • * The study analyzed data from the Korean National Health Insurance Service, examining two groups of dementia patients based on their diagnosis dates and tracking their follow-up for one year.
  • * Findings revealed a rise in follow-up loss from 42.04% to 45.89% among newly diagnosed dementia patients during the pandemic, with certain demographics (younger age, female sex, fewer health issues, etc.) linked to better follow-up and survival rates.
View Article and Find Full Text PDF

The radial artery has been used increasingly for percutaneous coronary intervention because of its safety and feasible access route. Nevertheless, transradial complications are possible because of the variation in radial artery anatomy. We experienced a case of the brachioradial artery injury secondary to catheterization, presenting as hypovolemic shock.

View Article and Find Full Text PDF
Article Synopsis
  • This study investigates the use of 16S rDNA next-generation sequencing (NGS) to improve the detection of bacterial infections in ascites fluid associated with liver cirrhosis.
  • The research involved 10 patients with suspected spontaneous bacterial peritonitis (SBP), comparing traditional ascites cultures with the advanced sequencing techniques.
  • Findings indicated that both methods showed low positivity rates and similar results, suggesting that the NGS method does not significantly enhance bacterial detection in ascitic fluid compared to conventional cultures.
View Article and Find Full Text PDF

Hyperbaric oxygen therapy (HBOT) has garnered significant attention as a therapeutic modality with potential benefits across a variety of medical conditions, ranging from wound healing and ischemic conditions to neurologic disorders and radiation-induced tissue damage. HBOT involves the administration of 100% oxygen at higher-than-atmospheric pressures, which increases the amount of oxygen dissolved in body fluids and tissues. Those elevated oxygen levels are proposed to facilitate tissue repair, reduce inflammation, and promote angiogenesis.

View Article and Find Full Text PDF

There are limited data on outcomes after implantation of everolimus-eluting stents (EES) in East Asian patients with small vessel coronary lesions. A total of 1,600 patients treated with XIENCE EES (Abbott Vascular, CA, USA) were divided into the small vessel group treated with one ≤2.5 mm stent (n=119) and the non-small vessel group treated with one ≥2.

View Article and Find Full Text PDF

Importance: Complete revascularization by non-infarct-related artery (IRA) percutaneous coronary intervention (PCI) in patients with acute myocardial infarction is standard practice to improve patient prognosis. However, it is unclear whether a fractional flow reserve (FFR)-guided or angiography-guided treatment strategy for non-IRA PCI would be more cost-effective.

Objective: To evaluate the cost-effectiveness of FFR-guided compared with angiography-guided PCI in patients with acute myocardial infarction and multivessel disease.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_session7aukiqu5v5huvoj4e93g30u1fe0mjhhv): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once