The competing controls of glaciers, precipitation, and vegetation on high-mountain fluvial sediment yields.

Investigating erosion and river sediment yield in high-mountain areas is crucial for understanding landscape and biogeochemical responses to environmental change. We compile data on contemporary fluvial suspended sediment yield (SSY) and 12 environmental proxies from 151 rivers in High Mountain Asia surrounding the Tibetan Plateau. We demonstrate that glaciers exert a first-order control on fluvial SSYs, with high precipitation nonlinearly amplifying their role, especially in high-glacier cover basins.

Shifted sediment-transport regimes by climate change and amplified hydrological variability in cryosphere-fed rivers.

Climate change affects cryosphere-fed rivers and alters seasonal sediment dynamics, affecting cyclical fluvial material supply and year-round water-food-energy provisions to downstream communities. Here, we demonstrate seasonal sediment-transport regime shifts from the 1960s to 2000s in four cryosphere-fed rivers characterized by glacial, nival, pluvial, and mixed regimes, respectively. Spring sees a shift toward pluvial-dominated sediment transport due to less snowmelt and more erosive rainfall.

Feasibility, Safety, and Technical Success of the Flying Intervention Team in Acute Ischemic Stroke : Comparison of Interventions in Different Primary Stroke Centers with those in a Comprehensive Stroke Center.

Background: Prompt endovascular care of patients with ischemic stroke due to large vessel occlusion (LVO) remains a major challenge in rural regions as primary stroke centers (PSC) usually cannot provide neuro-interventional services. Objective The core content of the Flying Intervention Team (FIT) project is to perform thrombectomy on-site at a local PSC after the neuro-interventionalist has been transported via helicopter to the target hospital. An important and so far unanswered question is whether mechanical thrombectomy can be performed as safely and successfully on-site as in a specialized comprehensive stroke center (CSC).

sp. NIVA-CYA 255, a Promising Candidate for Poly(3-hydroxybutyrate) Production under Mixotrophic Deficiency Conditions.

Cyanobacteria are a promising source for the sustainable production of biodegradable bioplastics such as poly(3-hydroxybutyrate) (PHB). The auto-phototrophic biomass formation is based on light and CO, which is an advantage compared to heterotrophic PHB-producing systems. So far, only a handful of cyanobacterial species suitable for the high-yield synthesis of PHB have been reported.

In situ quantification of poly(3-hydroxybutyrate) and biomass in Cupriavidus necator by a fluorescence spectroscopic assay.

Fluorescence spectroscopy offers a cheap, simple, and fast approach to monitor poly(3-hydroxybutyrate) (PHB) formation, a biodegradable polymer belonging to the biodegradable polyester class polyhydroxyalkanoates. In the present study, a fluorescence and side scatter-based spectroscopic setup was developed to monitor in situ biomass, and PHB formation of biotechnological applied Cupriavidus necator strain. To establish PHB quantification of C.

Exceptional increases in fluvial sediment fluxes in a warmer and wetter High Mountain Asia.

Rivers originating in High Mountain Asia are crucial lifelines for one-third of the world’s population. These fragile headwaters are now experiencing amplified climate change, glacier melt, and permafrost thaw. Observational data from 28 headwater basins demonstrate substantial increases in both annual runoff and annual sediment fluxes across the past six decades.

Satellite imaging reveals increased proportion of population exposed to floods.

Flooding affects more people than any other environmental hazard and hinders sustainable development. Investing in flood adaptation strategies may reduce the loss of life and livelihood caused by floods. Where and how floods occur and who is exposed are changing as a result of rapid urbanization, flood mitigation infrastructure and increasing settlements in floodplains.

On the Origin of Paroxysmal Depolarization Shifts: The Contribution of Ca1.x Channels as the Common Denominator of a Polymorphous Neuronal Discharge Pattern.

Since their discovery in the 1960s, the term paroxysmal depolarization shift (PDS) has been applied to a wide variety of reinforced neuronal discharge patterns. Occurrence of PDS as cellular correlates of electrographic spikes during latent phases of insult-induced rodent epilepsy models and their resemblance to giant depolarizing potentials (GDPs) nourished the idea that PDS may be involved in epileptogenesis. Both GDPs and - in analogy - PDS may lead to progressive changes of neuronal properties by generation of pulsatile intracellular Ca elevations.

Fast, inexpensive, and reliable HPLC method to determine monomer fractions in poly(3-hydroxybutyrate-co-3-hydroxyvalerate).

The determination of the monomer fractions in polyhydroxyalkanoates is of great importance for research on microbial-produced plastic material. The development of new process designs, the validation of mathematical models, and intelligent control strategies for production depend enormously on the correctness of the analyzed monomer fractions. Most of the available detection methods focus on the determination of the monomer fractions of the homopolymer poly(3-hydroxybutyrate).

Bet v 1 contiguous overlapping peptides anchored to virosomes with TLR4 agonist enhance immunotherapy efficacy in mice.

Background: Whereas sublingual allergen immunotherapy (AIT) is routinely performed without any adjuvant or delivery system, there is a strong scientific rationale to better target the allergen(s) to oral dendritic cells known to support regulatory immune responses by using appropriate presentation platforms.

Objective: To identify a safe presentation platform able to enhance allergen-specific tolerance induction.

Methods: Virosomes with membrane-integrated contiguous overlapping peptides (COPs) of Bet v 1 and TLR4 or TLR2/TLR7 agonists were assessed for induction of Bet v 1-specific IgG1, IgG2a and IgE antibodies, hypersensitivity reactions and body temperature drop following subcutaneous injection in naive CD-1 mice.

The use of LipidGreen2 for visualization and quantification of intracellular Poly(3-hydroxybutyrate) in .

Numerous studies have been conducted to develop a rapid protocol for the quantification of poly(3-hydroxybutyrate) during bacterial fermentation as an alternative to time-consuming gravimetric or analytical methods. Fluorescence spectroscopy is one of the most promising approaches. In this study, it could be demonstrated that the novel fluorescent probe LipidGreen2 is able to stain selectively poly(3-hydroxybutyrate) in .

Global-scale human impact on delta morphology has led to net land area gain.

River deltas rank among the most economically and ecologically valuable environments on Earth. Even in the absence of sea-level rise, deltas are increasingly vulnerable to coastal hazards as declining sediment supply and climate change alter their sediment budget, affecting delta morphology and possibly leading to erosion. However, the relationship between deltaic sediment budgets, oceanographic forces of waves and tides, and delta morphology has remained poorly quantified.

How Hydrologic Connectivity Regulates Water Quality in River Corridors.

Downstream flow in rivers is repeatedly delayed by hydrologic exchange with off-channel storage zones where biogeochemical processing occurs. We present a dimensionless metric that quantifies river connectivity as the balance between downstream flow and the exchange of water with the bed, banks, and floodplains. The degree of connectivity directly influences downstream water quality - too little connectivity limits the amount of river water exchanged and leads to biogeochemically inactive water storage, while too much connectivity limits the contact time with sediments for reactions to proceed.

Efficacy of 2 months of allergen-specific immunotherapy with Bet v 1-derived contiguous overlapping peptides in patients with allergic rhinoconjunctivitis: Results of a phase IIb study.

Background: An immunotherapy formulation consisting of 3 contiguous overlapping peptides (COPs) derived from Bet v 1, the major birch pollen allergen, showed good clinical tolerability in a previous phase I/IIa clinical trial.

Objectives: We sought to evaluate the efficacy and safety of allergen-specific immunotherapy using 2 dose regimens of Bet v 1 COPs versus placebo in subjects with birch pollen-induced allergic rhinoconjunctivitis.

Methods: A randomized, double-blind, placebo-controlled phase IIb clinical trial was performed to assess the efficacy of Bet v 1 COP immunotherapy during the 2013 birch pollen season.

Changes in water and sediment exchange between the Changjiang River and Poyang Lake under natural and anthropogenic conditions, China.

To study the fluvial interaction between Changjiang River and Poyang Lake, we analyze the observed changes of riverine flux of the mid-upstream of Changjiang River catchment, the five river systems of Poyang Lake and Poyang Lake basin. Inter-annual and seasonal variations of the water discharge and sediment exchange processes between Changjiang River and Poyang Lake are systematically explored to determine the influence of climate change as well as human impact (especially the Three Gorges Dam (TGD)). Results indicate that climate variation for the Changjiang catchment and Poyang Lake watershed is the main factor determining the changes of water exchanges between Changjiang River and Poyang Lake.

Fluvial response to climate variations and anthropogenic perturbations for the Ebro River, Spain in the last 4,000 years.

Fluvial sediment discharge can vary in response to climate changes and human activities, which in return influences human settlements and ecosystems through coastline progradation and retreat. To understand the mechanisms controlling the variations of fluvial water and sediment discharge for the Ebro drainage basin, Spain, we apply a hydrological model HydroTrend. Comparison of model results with a 47-year observational record (AD 1953-1999) suggests that the model adequately captures annual average water discharge (simulated 408 m(3)s(-1) versus observed 425 m(3)s(-1)) and sediment load (simulated 0.

Ear-worn reference data collection and annotation for multimodal context-aware hearing instruments.

In this work we present a newly developed ear-worn sensing and annotation device to unobtrusively capture head movements in real life situations. It has been designed in the context of developing multimodal hearing instruments (HIs), but is not limited to this application domain. The ear-worn device captures triaxial acceleration, rate of turn and magnetic field and features a one-button-approach for real-time data annotation through the user.

Early anthropogenic transformation of the Danube-Black Sea system.

Over the last century humans have altered the export of fluvial materials leading to significant changes in morphology, chemistry, and biology of the coastal ocean. Here we present sedimentary, paleoenvironmental and paleogenetic evidence to show that the Black Sea, a nearly enclosed marine basin, was affected by land use long before the changes of the Industrial Era. Although watershed hydroclimate was spatially and temporally variable over the last ~3000 years, surface salinity dropped systematically in the Black Sea.

Socio-economic impacts on flooding: a 4000-year history of the Yellow River, China.

We analyze 4000-year flood history of the lower Yellow River and the history of agricultural development in the middle river by investigating historical writings and quantitative time series data of environmental changes in the river basin. Flood dynamics are characterized by positive feedback loops, critical thresholds of natural processes, and abrupt transitions caused by socio-economic factors. Technological and organizational innovations were dominant driving forces of the flood history.

Sediment flux and the Anthropocene.

Data and computer simulations are reviewed to help better define the timing and magnitude of human influence on sediment flux--the Anthropocene epoch. Impacts on the Earth surface processes are not spatially or temporally homogeneous. Human influences on this sediment flux have a secondary effect on floodplain and delta-plain functions and sediment dispersal into the coastal ocean.

Insulin potentiates FcepsilonRI-mediated signaling in mouse bone marrow-derived mast cells.

Factors contained in physiological microenvironments in tissues where mast cells differentiate and reside may influence mast cell responsiveness and modify antigen-dependent activation. A possible direct or indirect role of mast cell responses in diabetes mellitus prompted us to study the impact of insulin treatment on antigen triggered signaling pathways downstream of FcepsilonRI in bone marrow-derived mouse mast cells (BMMCs). We found that insulin alone stimulates tyrosine phosphorylation of tyrosine kinases Lyn, Syk, Fyn, the adapter protein Gab2 (Grb2-associated binding protein 2), Akt and activates ERK, JNK and p38 kinase.