A Prognostic Model Based on Clinical Biomarkers for Heart Failure in Adult Patients Following Allogeneic Hematopoietic Stem Cell Transplantation.

Heart failure (HF) is an uncommon but serious cardiovascular complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Unfortunately, knowledge about early mortality prognostic factors in patients with HF after allo-HSCT is limited, and an easy-to-use prognostic model is not available. This study aimed to develop and validate a clinical-biomarker prognostic model capable of predicting HF mortality following allo-HSCT that uses a combination of variables readily available in clinical practice.

Chromosomal microarray analysis versus noninvasive prenatal testing in fetuses with increased nuchal translucency.

Objective: To evaluate if the NT value of 2.5 mm ≤ NT < 3.0 mm is an appropriate indication for CMA tests among fetuses with isolated increased NT and NIPT is more suitable instead.

Expanding the application of non-invasive prenatal testing in the detection of foetal chromosomal copy number variations.

Purpose: The aim of this study was to assess the detection efficiency and clinical application value of non-invasive prenatal testing (NIPT) for foetal copy number variants (CNVs) in clinical samples from 39,002 prospective cases.

Methods: A total of 39,002 pregnant women who received NIPT by next-generation sequencing (NGS) with a sequencing depth of 6 M reads in our centre from January 2018 to April 2020 were enrolled. Chromosomal microarray analysis (CMA) was further used to diagnose suspected chromosomal aneuploidies and chromosomal microdeletion/microduplication for consistency assessment.

Experimental and Analytical Study on Creep Characteristics of Box Section Bamboo-Steel Composite Columns under Long-Term Loading.

To expand the application of bamboo as a building material, a new type of box section composite column that combined bamboo and steel was considered in this paper. The creep characteristics of eight bamboo-steel composite columns with different parameters were tested to evaluate the effects of load level, section size and interface type under long-term loading. Then, the deformation development of the composite column under long-term loading was observed and analyzed.

Noninvasive prenatal testing for assessing foetal sex chromosome aneuploidy: a retrospective study of 45,773 cases.

Objective: To assess the positive predictive value (PPV) of noninvasive prenatal testing (NIPT) as a screening test for sex chromosome aneuploidy (SCA) with different maternal characteristics and prenatal decisions in positive cases.

Materials And Methods: We retrospectively analysed 45,773 singleton pregnancies with different characteristics that were subjected to NIPT in the Maternity and Child Health Hospital of Anhui Province. The results were validated by karyotyping.

[Application of in situ amniocyte culture for prenatal diagnosis].

Objective: To explore the value of in situ amniocyte culture for prenatal diagnosis.

Methods: 2716 amniotic fluid samples were cultured in situ on slides. After the culture, the slides were stained, photographed and analyzed.