Stability-Indicating TLC-Densitometric and HPLC Methods for Simultaneous Determination of Teneligliptin and Pioglitazone in Pharmaceutical Dosage Forms with Eco-Friendly Assessment.

The combination of teneligliptin hydrobromide hydrate and pioglitazone hydrochloride in pharmaceutical formulations has improved type 2 diabetes management. Two chromatographic methods TLC-densitometry and RP-HPLC were developed for simultaneous quantification of teneligliptin hydrobromide hydrate and pioglitazone hydrochloride in pharmaceutical formulations, ensuring accuracy and stability assessment. The TLC method uses a mobile phase of methanol, toluene, ethyl acetate and triethylamine (1:7:2:0.

Development and Validation of HPLC Analytical Method for Chlorantraniliprole in Bulk and in the Formulation.

Background: Chlorantraniliprole is widely used as a pesticide. It is only soluble in dimethyl formamide. However, most of the reported methods used acetonitrile and other solvents.

Nuts and Bolts of Oil and Temperature in Topical Preparations of Salicylic Acid.

Background: Traditional formulations of salicylic acid in ointment bases have disadvantages of being greasy and irritant due to free crystals.

Aim: To explore the method for selection of oils and their ratio for topical preparation on the basis of equilibrium solubility study of salicylic acid and to evaluate temperature effect.

Materials And Methods: Scanning and calibration curve of salicylic acid in methanol were developed.

Association of Permeability and Lipid Content of Membrane.

Background: Rat skin and goat cul de sac are mostly used in optimization of formulations as the model of human skin and cul de sac.

Aim: To explore the correlation between lipid content of rat skin and goat cul de sac and permeability.

Materials And Methods: Find out wavelength maximum for Sapat plus malam®, Ciplox eye ointment® and chloramphenicol eye caps and the standard curve was also derived.

Emulsion of Chloramphenicol: an Overwhelming Approach for Ocular Delivery.

Background: Ophthalmic formulations of chloramphenicol have poor bioavailability of chloramphenicol in the ocular cavity.

Aim: The present study aimed at exploring the impact of different oil mixtures in the form of emulsion on the permeability of chloramphenicol after ocular application.

Materials And Methods: Selection of oil mixture and ratio of the components was made by an equilibrium solubility method.