Hitchhiking microbes: Declining biodiversity & emerging zoonoses.

The connection between nature conservation and human wellbeing is well known, however, the role of declining biodiversity and emerging diseases is relatively less studied. The presence of a thriving biological diversity is known to have therapeutic effects on human health. On the other hand, human economic activities have contributed to a sharp decline in species, resulting in poor ecosystem health.

Targeting Janus tyrosine kinase 3 (JAK3) with an inhibitor induces secretion of TGF-β by CD4+ T cells.

Regulatory T cells (Tregs) are critical for the peripheral maintenance of the autoreactive T cells in autoimmune disorders such as type 1 diabetes (T1D). Pharmacological inhibition of Janus tyrosine kinase 3 (JAK3) has been proposed as a basis for new treatment modalities against autoimmunity and allogeneic responses. Targeting JAK3 with an inhibitor has previously been shown to exhibit protective action against the development of T1D in non-obese diabetic (NOD) mice.