Publications by authors named "Ketai Yan"
Article Synopsis
- Aplastic anemia (AA) is a bone marrow failure syndrome caused by hyperactive T-cells, but its exact causes and onset are still not well understood.
- This study uses advanced techniques like single-cell RNA sequencing and multi-omics analyses to create a cellular map of AA, identifying a new subset of regulatory T-cells that is important for maintaining immune balance.
- Key findings include impaired immune regulation, cell death mechanisms affecting hematopoietic stem cells, and the identification of ferroptosis as a major factor in cell destruction, offering new avenues for treatment development.
CCL17 acts as an antitumor chemokine in micromilieu-driven immune skewing.
Int Immunopharmacol
May 2023
Background: Chemokines are critical players in the local immune responses to tumors. CCL17 (thymus and activation-regulated chemokine, TARC) and CCL22 (macrophage-derived chemokine, MDC) can attract CCR4-bearing cells involving the immune landscape of cancer. However, their direct roles and functional states in tumors remain largely unclear.
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