Publications by authors named "Keshtkar A"

Early prediction of poor outcomes in patients impacted with aneurysmal subarachnoid hemorrhage (aSAH) is crucial for timely intervention and effective management. This systematic review and meta-analysis aimed to evaluate the performance of machine learning (ML) algorithms in predicting poor outcomes in patients with aSAH, assessing their sensitivity, specificity, and other algorithm metrics. A comprehensive search of PubMed, Scopus, Embase, Web of science and Cochrane library conducted to identify eligible studies.

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  • The study highlighted the rising threat of resistance to colistin, the last line of defense against severe infections, which is becoming a major public health issue.
  • A thorough analysis of 619 studies indicated a global colistin resistance prevalence of 1%, with cystic fibrosis patients showing a significantly higher rate of 7%.
  • The findings reveal an alarming increase in colistin resistance over recent years, stressing the urgent need for improved infection control and awareness of antimicrobial resistance.
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  • Clinical reasoning is a key competency in medicine that involves using knowledge and skills to diagnose problems, implement interventions, and enhance patient care, making it crucial for medical students to develop this skill.
  • The scoping review aimed to summarize existing literature on teaching methods to improve clinical reasoning in undergraduate medical education by analyzing articles published from 2010 to 2024.
  • The review included 54 studies that explored various educational strategies for enhancing clinical reasoning, highlighting the need for more precise and larger-scale research to obtain definitive conclusions.
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Background: Metabolic syndrome (MetS) prevalence has increased globally.The evidence shows thatdiet and gut microbial metabolites includingtrimethylamine N-oxide (TMAO) and kynurenine (KYN) play an important role in developing MetS. However, there is a lack of evidence on associations between between diet and these metabolites.

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Background: Diabetes mellitus is a chronic metabolic disorder with substantial implications for public health. Understanding the factors influencing blood sugar fluctuations is crucial for effective diabetes management and prevention. This study aimed to evaluate factors associated with blood sugar changes in diabetic patients and healthy individuals attending the Sabzevar Persian Cohort Center, employing the growth curve model.

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  • The study focused on the prevalence of pre-existing asymmetry in patients undergoing upper eyelid surgery and how age and sex influence this asymmetry.
  • Of the 155 patients analyzed, 72% had some level of asymmetry, with males under 50 showing the most significant differences in upper facial measurements.
  • The findings emphasize the importance of recognizing facial asymmetry before surgery to manage patient expectations and reduce potential dissatisfaction with post-operative results.
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Background: Considering the importance of the nose in the beauty of the face, accurate and systematic three-dimensional nasal analysis of the nose before the procedure is essential. The radix, and so the nasofrontal and nasofacial angles, play an essential role in forming an aesthetically pleasing nose because they influence the length and projection of the nose. We aimed to measure information about the pre-operative radix position in our region.

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Due to the limited reserves of uranium, the abundance of thorium compared to it and other advantages, the development of the thorium fuel cycle is of interest in different countries. The optimization of thorium extraction from a feed solution produced by Saghand ore with bis(2,4,4-trimethylpentyl) phosphinic acid (Cyanex 272) on a laboratory scale was evaluated by response surface method. The operating variables include Cyanex 272 concentration of 0.

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Objective: Evaluate methodological quality of type 2 diabetes RCTs conducted in Iran and cited in clinical practice guidelines and systematic reviews and meta-analyses.

Methods: We conducted a descriptive methodological quality review, analyzing 286 Randomized Controlled Trials (RCTs) on diabetes mellitus published in Iran from July 2004 to 2021. We searched six databases systematically and evaluated eligible articles using the CONSORT 2010 checklist for abstracts.

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Background: Sepsis is a life-threatening disorder with no definitive cure. Preclinical studies suggest that extracellular vesicles derived from mesenchymal stromal cells (EV-MSCs) can mitigate inflammatory conditions, potentially leading to increased survival and reduced organ dysfunction during sepsis. Our aim to conduct this systematic review and meta-analysis is assessing the EV-MSCs therapeutic efficacy in sepsis.

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Background: The first 1000 days of life are critical for a child's health and development. Impaired growth during this period is linked to increased child morbidity, mortality, and long-term consequences. Undernutrition is the main cause, and addressing it within the first 1000 days of life is vital.

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Background And Objective: Patients with heart failure experience high hospitalization. However, patients cannot recognize symptoms according to current approaches, which needs to be improved by new self-monitoring instruments and strategies. Thus, we aimed to assess a self-monitoring traffic light diary on outcomes of patients with heart failure.

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Introduction: Superior mesenteric artery (SMA) syndrome is a rare duodenal-vascular anatomic disorder leading to external compression on the duodenum. The first step of treatment usually is conservative, and in the case of failure, surgical management is the treatment choice. Treatment success with duodenojejunostomy after failure in gastrojejunostomy can show the uniqueness of this article.

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Background: Epidemiologic research suggests that gut microbiota alteration (dysbiosis) may play a role in the pathogenesis of metabolic syndrome (MetS). Dysbiosis can influence Trimethylamine N-oxide (TMAO) a gut microbiota-derived metabolite, as well as kynurenine pathways (KP), which are known as a new marker for an early predictor of chronic diseases. Hence, the current study aimed to investigate the association between KYN and TMAO with MetS and its components.

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Background: COVID-19, caused by SARS-CoV-2, is a global pandemic that particularly affects immunocompromised individuals, leading to secondary bacterial and fungal infections. Mucormycosis, caused by Mucorales fungi, is a severe infection primarily affecting immunocompromised individuals. The COVID-19 pandemic has seen a surge in mucormycosis cases worldwide, with India experiencing a significant increase.

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Mucocele is a benign soft tissue mass that could occur in all accessory glands. Mucocele can also occur in paranasal sinuses. It is mostly placed in the frontal sinus and barely grows larger than 1.

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Background: Randomized controlled trials (RCTs) provide the strongest evidence for therapeutic interventions and their effects on groups of subjects. However, the large amount of unstructured information in these trials makes it challenging and time-consuming to make decisions and identify important concepts and valid evidence. This study aims to explore methods for automating or semi-automating information extraction from reports of RCT studies.

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Background: Previous studies have shown that the intake of nitrate and nitrite may be associated with cardiovascular disease. Therefore, this study sought to investigate the association between dietary intakes of nitrate and nitrite with the odds of angina and atherogenic index in adults.

Methods: The study analyzed 1182 adults aged 20+ in the Tehran University of Medical Sciences (TUMS) Employee's Cohort study (TEC), focusing on dietary intakes, angina, and atherogenic indexes, using a validated food frequency questionnaire (FFQ) and the Rose Angina Questionnaire (RAQ).

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  • Posttransplant lymphoproliferative disorder (PTLD) can occur after organ transplantation due to Epstein-Barr virus (EBV) in patients on immunosuppressants, with a potential rise in cases noted during the COVID-19 pandemic, particularly involving gastrointestinal symptoms.
  • A case series highlighted five young Iranian patients post-liver transplantation who exhibited gastrointestinal PTLD, all showing similar EBV status and related COVID-19 exposure.
  • Despite receiving chemotherapy, only two out of the five patients survived, emphasizing the need for early diagnosis methods for PTLD before severe complications arise.
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  • Convolutional neural networks (CNNs) are used in clinical settings to enhance the detection of colorectal lesions, specifically polyps and cancer.
  • A systematic review analyzed 24 studies to evaluate their performance, revealing that CNN models achieved high sensitivity and specificity for both conditions under varying accuracy scenarios.
  • Overall, the models demonstrated reliable diagnostic capabilities, with promising metrics indicating their effectiveness in detecting colorectal polyps and cancer.
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Unlike improved treatment response in multiple myeloma (MM), the mortality rate in MM is still high. The study's aim is to investigate the potential role of circRNAs as a new biomarker for diagnosis, prognosis, and clinicopathological features of MM. We identified studies through Web of Science, Scopus, PubMed and ProQuest databases, and Google Scholar to August 2022.

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Background: Medical errors cause disability and mortality in intensive care units (ICUs). We aimed to determine the occurrence and causes of medical errors in the ICUs of Iran.

Methods: In this cross-sectional study, data from the family complaint files referred to The disciplinary authority of Iran Medical Council was retrospectively reviewed to explore the causes of medical errors.

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Purpose: To compare the difference of marginal level changes (MBL), implant failure (IF), biological and prosthetic complications (BC and PC), and prosthetic failure (PF) of short implants (SH) and standard implants (ST).

Materials And Methods: Electronic searches (PubMed, Web of Science, EMBASE, Scopus, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov) and manual searches were performed to identify all randomized controlled trials (RCTs) evaluating SH to ST.

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Aims: More than three decades have passed since the end of the Iraq-Iran war, and this period has been concurrent with a rapid growth of the older community in Iran which includes the community of veterans who often suffer from serious psychological and behavioral problems. The study aimed to investigate the prevalence and determinants of loneliness in middle and older veterans in southern Iran.

Materials & Methods: A cross-sectional study conducted among 583 middle and older male veterans (50 years <) who were selected by the census method in 2021.

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