The temporal course of mucoperiosteal flap revascularization at guided bone regeneration-treated implant sites: a pilot study.

Aims: To investigate post-operative capillary density regeneration in healing mucoperiosteal flaps at guided bone regeneration-treated implant sites.

Material And Methods: A non-invasive post-operative investigation was performed in 10 patients using orthogonal polarization spectral (OPS) imaging for assessment of capillary density during the course of mucoperiosteal flap wound healing for 6 weeks in patients receiving dental implants.

Results: The greatest increase in capillary regeneration occurred in the early wound-healing phase, during weeks 1 and 2, and recovery to baseline was achieved between weeks 4 and 5.

Microvascular soft tissue changes in alveolar distraction osteogenesis.

Objective: The aim of the study was to quantify the effect of distraction osteogenesis on the changes in vascular density in the human oral mucosa.

Material And Methods: Alveolar distraction was performed in 10 patients with alveolar ridge deficiencies, while in the contralateral nondistracted site an implant was placed. The distraction device was activated after 7 days of latency starting with a distraction rate of 1 mm a day for a 1-week period.

Cardiac resynchronization improves microcirculation.

Background: Although it is known that cardiac resynchronization therapy (CRT) in heart failure (HF) patients improves systemic circulation, its acute effects on microcirculation are as yet unknown. Therefore we investigated the sublingual microcirculatory changes in HF patients from CRT and right ventricular (RV) pacing by use of orthogonal polarization spectral (OPS) imaging.

Methods And Results: Twelve consecutive HF patients with a CRT device and 20 healthy individuals (HI) were included.

Influence of the application of platelet-enriched plasma in oral mucosal wound healing.

Purpose: The aim of this study was to describe and quantify the therapeutic value of platelet concentrate on the capillary density in oral mucosal wound healing.

Material And Methods: The subjects included 10 healthy edentulous patients who underwent bilaterally a sinus floor elevation procedure and a buccal onlay graft with autologous iliac crest bone for maxillary reconstruction. During surgery, platelet-rich plasma (PRP) was prepared from a blood sample taken from the patient.

Orthogonal polarization spectral (OPS) imaging and topographical characteristics of oral squamous cell carcinoma.

Tumor microcirculatory characteristics until now have only been assessed by histological examination of biopsies or invasive imaging technique. The recent introduction of orthogonal polarization spectral (OPS) imaging as a new tool for in vivo visualization of human microcirculation makes it possible to acquire high resolution images of the oral mucosa. In this study we report the microcirculatory changes in ten patients with oral squamous cell carcinoma of the tongue and compared the images to the normal contralateral side as the control.

Quantifying bedside-derived imaging of microcirculatory abnormalities in septic patients: a prospective validation study.

Introduction: The introduction of orthogonal polarization spectral (OPS) imaging in clinical research has elucidated new perspectives on the role of microcirculatory flow abnormalities in the pathogenesis of sepsis. Essential to the process of understanding and reproducing these abnormalities is the method of quantification of flow scores.

Methods: In a consensus meeting with collaboraters from six research centres in different fields of experience with microcirculatory OPS imaging, premeditated qualifications for a simple, translucent and reproducible way of flow scoring were defined.

Nitroglycerin in septic shock after intravascular volume resuscitation.

In patients with septic shock, oxygen consumption is increased, but oxygen delivery and extraction is impaired, partly because of microcirculatory shutdown and shunting. Orthogonal polarisation spectral (OPS) imaging allows visualisation of the microcirculation. We used this technique to assess microcirculatory flow in septic-shock patients who had a mean arterial blood pressure of more than 60 mm Hg and central venous pressure greater than 12 mm Hg.