Publications by authors named "Kesavapisharady Krishnakumar"

Spontaneous dorsal cord herniations are very rare, with only 3 reported cases published in the literature. We report a case of a 15-year-old girl, presenting with progressive symptoms of myelopathy, diagnosed with dorsal cord herniation. She was managed surgically.

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Article Synopsis
  • This study evaluates the surgical outcomes for pediatric patients with primary spinal arachnoid cysts (SACs) that cause compressive myelopathy, updating classification and management approaches.
  • The analysis included 17 children, revealing that cysts typically extended over 5.2 vertebral levels and were often intradural, with surgical procedures divided between laminectomy and laminoplasty; post-operative spinal deformities were infrequent, especially in the laminoplasty group.
  • The findings suggest that marsupialization or microsurgical excision are effective for managing symptomatic SACs, and laminoplasty is recommended to minimize the risk of spinal deformities in growing children.
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Cortico-amygdalo-hippocampectomy is the most common epilepsy surgery resection in adults and offers excellent outcomes. Seizure outcome benefits range from 75% to 88% with a 2%-4% adverse event rate. The safety profile and outcomes could be enhanced further by clearly defining key surgical landmarks that could also aid tumoral resections in the mesial temporal lobe and selective mesial resections.

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Background: Deep brain stimulation (DBS) is the most widely used device-assisted therapy in patients with moderately advanced stages of Parkinson's disease (PD) experiencing motor complications. Only a minority of eligible patients get the opportunity to undergo DBS in the developing world.

Objectives: To examine the proportion and characteristics of patients with motor complications of PD who are willing for DBS and who undergo surgery.

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Objective: We sought to reclassify the "anatomic risk zones of colloid cysts" as proposed by Beaumont et al, by proposing newer landmarks, and to assess predictive value for the risk of occurrence of hydrocephalus with the new classification compared with the old.

Methods: A retrospective cohort of 122 cases of colloid cyst of third ventricle were categorized into zones 1, 2, or 3 based on Beaumont's classification (old zone) and our classification (new zone) based on radiologic images. We attempted to recategorize these zones by assigning new anatomic landmarks.

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Objective: We sought to analyze the evolution of hydrocephalus and enumerate its predictive factors in posterior fossa tumors in children and adults. We also validated the modified Canadian Preoperative Prediction Rule for Hydrocephalus (mCPPRH) and Frankfurt grading systems as tools to predict cerebrospinal fluid (CSF) diversion in children and adults, respectively.

Methods: A retrospective review of patients with posterior fossa tumors operated between 2012 and 2019 was performed.

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Autologous blood transfusion is known to have advantages over allogeneic transfusion. The COVID-19 pandemic intensified the already existing shortage of allogeneic blood supply. We carried out a study during this period with the aim to elicit the effects of autologous blood collection and transfusion, to compare the peri-operative outcomes of autologous and allogeneic transfusion practices and also to assess the influence of the autologous transfusion programme in the Blood Centre inventory.

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Nonneoplastic epithelial cysts involving the central nervous system are diverse and are predominantly developmental in origin. This study represents a surgical series describing the histopathological features of 507 such epithelial cysts with clinical and imaging correlation. Age at surgery ranged from 7 months to 72 years (mean: 33 years) affecting 246 male and 261 female patients.

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This report describes a very rare Dandy-Walker malformation (DWM) associated with neurofibromatosis (NF) and bony defect over torcula emphasizing the role of meticulous follow-up for asymptomatic DWM. The clinical aspects of an adolescent patient with undiagnosed DWM who was asymptomatic until the age of 14 years are being discussed. Computed tomography and magnetic resonance imaging were revealed DWM.

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Background: Spinal intramedullary cysts present a radiological dilemma. We present a rare case of a conus intramedullary arachnoid cyst and report on its differentiating features and management.

Case Description: We report a case of a 30-month-old child who presented with decreased gluteal sensation and urinary dribbling for 6 months.

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Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor symptoms and motor complications of Parkinson's disease (PD). The intervention is expected to result in some cognitive changes, the nature of which is not uniform across the studies which have reported them. PD itself is associated with progressive cognitive decline and hence longitudinal follow-up studies with medically managed control group of patients are needed to explore the cognitive deficits attributable to DBS.

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Purpose: Compressive vertebral hemangiomas with neurological deficits (CVHND) form a rare, unique subset of lesions comprising of differing clinico-imaging findings, pathologic behavior and treatment, when compared to the commoner and usually incidental intra-osseus vertebral hemangiomas (VH). Though various surgical strategies and a broad array of adjuncts have evolved and changed over the years, there is paucity of comprehensive data from sizeable series of such patients treated surgically with long term follow up. The purpose of this study is to device an optimum management strategy in CVHND based on our surgical experience.

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Aim: To study the clinical profile, imaging features, intra-operative findings, post-operative outcome at discharge and at 6 months in patients with internal carotid artery (ICA) bifurcation aneurysm.

Material And Methods: Present study is a retrospective analysis of data of patients who underwent surgery for ICA bifurcation aneurysm between the period of 1st January 2011 to 31st December 2015 at our institute. Demographic variable, clinical grade, radiological finding was assessed.

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Article Synopsis
  • New-onset apraxia of lid opening (ALO) develops in about 9.1% of Parkinson's disease patients after undergoing Deep Brain Stimulation (DBS), typically starting around 17 months post-surgery.
  • Older patients and those with non-tremor dominant Parkinson's subtypes are more likely to experience ALO.
  • Botulinum toxin therapy is effective in improving symptoms, while adjustments to medications or stimulation parameters show limited success.
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Background: Freezing of gait (FOG) is a disabling and refractory symptom of advanced Parkinson's disease (PD). Interleaved stimulation (ILS) is a novel paradigm which may benefit axial symptoms of PD.

Objectives: To assess the effect of ILS on FOG in patients unresponsive to conventional subthalamic nucleus (STN) stimulation.

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  • This study followed 14 patients treated for spinal hemangioblastomas to understand their clinical profiles, surgical complications, and long-term outcomes.
  • Despite being benign tumors, spinal hemangioblastomas can lead to significant neurological issues, and 50% of the patients in the study were found to have von Hippel-Lindau (VHL) disease, which is linked to these tumors.
  • The results highlighted that while immediate postoperative neurological decline was common, by the 5-year follow-up, 78.57% of patients had positive functional outcomes after complete tumor removal.
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  • * Results showed a significant decrease in mean flow velocity and estimated cerebral perfusion pressure, while values for pulsatility index, cerebral vascular resistance index, and zero flow pressure increased post-infusion.
  • * The findings suggest that dexmedetomidine may increase cerebral vascular resistance and reduce cerebral perfusion, which could be problematic for patients with existing neurological conditions, indicating a need for further research in this area.
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Background: Dexmedetomidine has been widely used in neuroanesthesia and critical care settings. The effects of dexmedetomidine on cerebral vascular autoregulation and hemodynamics in patients with intracranial pathology are not well defined. This study is aimed to address this issue.

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