Publications by authors named "Kesavan Harikrishnan"
Herein, a straightforward facile synthesis of indolo[2,3-]quinoline analogues was reported from 2-arylamino(phenylsulfonyl)methylindoles involving PIDA/BF·OEt-mediated intramolecular dehydrogenative coupling (IDC) as a key step. Even though isomeric 3-arylamino(phenylsulfonyl)methylindoles, upon interaction with PIDA/BF·OEt, led to complications, synthesis of the indolo[3,2-]quinoline framework could be easily achieved from -(2-iodoaryl)--indolylmethylbenzenesulfonamide by employing a Pd(0)-mediated intramolecular cyclization reaction. Under identical conditions, synthesis of indolo[2,3-]quinolines was also accomplished from the respective -(2-iodoaryl)--indolylmethylbenzenesulfonamides.
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- An intramolecular Diels-Alder reaction was used to synthesize quino[4,3-]carbazole and its derivatives from indole-2/3-phenylvinyl-alkynylated amines.
- The reaction involves a [4 + 2] cycloaddition followed by steps that eliminate and deprotect phenylsulfonyl groups, resulting in moderate to good yields and showcasing a wide range of compatible substrates.
- Preliminary tests revealed that several fluorine-containing quinocarbazoles demonstrated significant cytotoxic activity against human cancer cells, with unique fluorescence properties indicating the presence of tautomeric forms.