Publications by authors named "Kerstin Wohlgemuth"
Article Synopsis
- Human cytomegalovirus (HCMV) can cause serious birth defects, and currently, there is no vaccine available.
- Researchers tested live attenuated vaccine viruses created from CMV mutants lacking STAT2 antagonists in mice, which showed promising immune responses and protection against infections.
- Female mice vaccinated before pregnancy passed protective antibodies to their offspring, highlighting the critical role of maternal antibodies in providing immunity against HCMV in congenital infections.
Article Synopsis
- The COVID-19 pandemic has created a significant need for affordable and effective treatments, especially as the search for alternative therapies continues even with vaccine availability.
- Research tested herbal teas, specifically those made from perilla and sage, and found that they have strong antiviral effects against SARS-CoV-2, performing comparably to some existing treatments.
- Key compounds like caffeic acid and perilla aldehyde were identified in these teas, and the study suggests they work by activating certain protective mechanisms in the body, indicating potential for herbal remedies in managing COVID-19.
There is an increasing focus on two-phase flow in micro- or mini-structured apparatuses for various manufacturing and measurement instrumentation applications, including the field of crystallization as a separation technique. The slug flow pattern offers salient features for producing high-quality products, since narrow residence time distribution of liquid and solid phases, intensified mixing and heat exchange, and an enhanced particle suspension are achieved despite laminar flow conditions. Due to its unique features, the slug flow crystallizer (SFC) represents a promising concept for small-scale continuous crystallization achieving high-quality active pharmaceutical ingredients (API).
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- Primary and recurrent cytomegalovirus (CMV) infections can lead to CMV colitis, affecting both immunocompromised individuals and those with inflammatory bowel disease (IBD), with rare instances in immunocompetent patients.
- A study using a mouse model showed that acute primary MCMV infection changes gut microbial composition and leads to significant replication of the virus in the colon, along with increased inflammation and cell growth in the intestinal lining.
- The research found that CMV directly infects intestinal cells, causing increased cell death and disrupting the epithelial barrier, suggesting that CMV can temporarily cause colitis by disturbing the gut's balance in healthy individuals.
Immunization vectors based on cytomegalovirus (CMV) have attracted a lot of interest in recent years because of their high efficacy in the simian immunodeficiency virus (SIV) macaque model, which has been attributed to their ability to induce strong, unusually broad, and unconventionally restricted CD8+ T cell responses. To evaluate the ability of CMV-based vectors to mediate protection by other immune mechanisms, we evaluated a mouse CMV (MCMV)-based vector encoding Friend virus (FV) envelope (Env), which lacks any known CD8+ T cell epitopes, for its protective efficacy in the FV mouse model. When we immunized highly FV-susceptible mice with the Env-encoding MCMV vector (MCMV.
View Article and Find Full Text PDFA pathogen encounter induces interferons, which signal via Janus kinases and STAT transcription factors to establish an antiviral state. However, the host and pathogens are situated in a continuous arms race which shapes host evolution toward optimized immune responses and the pathogens toward enhanced immune-evasive properties. Mouse cytomegalovirus (MCMV) counteracts interferon responses by pM27-mediated degradation of STAT2, which directly affects the signaling of type I as well as type III interferons.
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