Global expression patterns of -genes in tomato and potato.

Introduction: As key-players of plant immunity, the proteins encoded by resistance genes (-genes) recognize pathogens and initiate pathogen-specific defense responses. The expression of some -genes carry fitness costs and therefore inducible immune responses are likely advantageous. To what degree inducible resistance driven by -genes is triggered by pathogen infection is currently an open question.

Muscle-relevant genes marked by stable H3K4me2/3 profiles and enriched MyoD binding during myogenic differentiation.

Post-translational modifications of histones play a key role in the regulation of gene expression during development and differentiation. Numerous studies have shown the dynamics of combinatorial regulation by transcription factors and histone modifications, in the sense that different combinations lead to distinct expression outcomes. Here, we investigated gene regulation by stable enrichment patterns of histone marks H3K4me2 and H3K4me3 in combination with the chromatin binding of the muscle tissue-specific transcription factor MyoD during myogenic differentiation of C2C12 cells.

Comparative DNA methylation and gene expression analysis identifies novel genes for structural congenital heart diseases.

Aims: For the majority of congenital heart diseases (CHDs), the full complexity of the causative molecular network, which is driven by genetic, epigenetic, and environmental factors, is yet to be elucidated. Epigenetic alterations are suggested to play a pivotal role in modulating the phenotypic expression of CHDs and their clinical course during life. Candidate approaches implied that DNA methylation might have a developmental role in CHD and contributes to the long-term progress of non-structural cardiac diseases.

Phosphorylation of the chromatin remodeling factor DPF3a induces cardiac hypertrophy through releasing HEY repressors from DNA.

DPF3 (BAF45c) is a member of the BAF chromatin remodeling complex. Two isoforms have been described, namely DPF3a and DPF3b. The latter binds to acetylated and methylated lysine residues of histones.

Psychosocial predictors and correlates for chronic post-surgical pain (CPSP) - a systematic review.

Chronic post-surgical pain (CPSP) is a serious problem. Incidence as high as 50% has been reported, depending on type of surgery undergone. Because the etiology of chronic pain is grounded in the bio-psychosocial model, physical, psychological, and social factors are implicated in the development of CPSP.

In vitro fracture resistance of four-unit fiber-reinforced composite fixed partial dentures.

Objectives: The aim of this in vitro study was to investigate the influence of glass fiber-reinforcement on the fracture resistance of four-unit composite fixed partial dentures (FPDs) in the posterior region.

Methods: A total of 70 FPDs were fabricated of the composites Sinfony, Vita Zeta and Targis. With each material, 10 FPDs were made without glass fiber-reinforcement and 10 were reinforced with the new glass fiber system EverStick.