Role of FGF Receptors and Their Pathways in Adrenocortical Tumors and Possible Therapeutic Implications.

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy and treatment of advanced disease is challenging. Clinical trials with multi-tyrosine kinase inhibitors in the past have yielded disappointing results. Here, we investigated fibroblast growth factor (FGF) receptors and their pathways in adrenocortical tumors as potential treatment targets.

PKA Cα subunit mutation triggers caspase-dependent RIIβ subunit degradation via Ser phosphorylation.

Mutations in the gene are the most frequent cause of cortisol-producing adrenocortical adenomas leading to Cushing's syndrome. encodes for the catalytic subunit α of protein kinase A (PKA). We already showed that mutations lead to impairment of regulatory (R) subunit binding.