Equalizing transcallosal inhibition in the mouse anterior cingulate mitigates visuospatial neglect.

A recent study by Wang and colleagues disentangled a transcallosal inhibitory circuit in mouse anterior cingulate cortex (ACC), which modulates excitatory ipsilateral tonus and contralateral inhibition by exciting contralateral parvalbumin-positive (PV+) interneurons. The authors conclude that the identified circuit mediates interhemispheric balance for visuospatial attention and provides top-down modulation of visual cortices.

Selective interhemispheric circuits account for a cardinal bias in spontaneous activity within early visual areas.

Ongoing brain activity exhibits patterns resembling neural ensembles co-activated by stimulation or task performance. Such patterns have been attributed to the brain's functional architecture, e.g.