Localized interstitial pulmonary amyloid: a case report and review of the literature.

Purpose Of Review: Diffuse interstitial pulmonary amyloidosis is a fatal disorder that is rare and often undiagnosed. There are many documented cases of diffuse interstitial amyloid occurring with systemic amyloid light-chain amyloid. We present an extraordinary case of localized interstitial amyloidosis, making our case the eleventh documented in the literature.

Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor kappaB by an AKT-independent pathway.

Purpose: The purpose of this study was to determine whether a liposomal formulation of curcumin would suppress the growth of head and neck squamous cell carcinoma (HNSCC) cell lines CAL27 and UM-SCC1 in vitro and in vivo.

Experimental Design: HNSCC cell lines were treated with liposomal curcumin at different doses and assayed for in vitro growth suppression using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. A reporter gene assay was done on cell lines to study the effect of liposomal curcumin on nuclear factor kappaB (NFkappaB) activation.