Albuminuria-Related Genetic Biomarkers: Replication and Predictive Evaluation in Individuals with and without Diabetes from the UK Biobank.

Increased albuminuria indicates underlying glomerular pathology and is associated with worse renal disease outcomes, especially in diabetic kidney disease. Many single nucleotide polymorphisms (SNPs), associated with albuminuria, could be potentially useful to construct polygenic risk scores (PRSs) for kidney disease. We investigated the diagnostic accuracy of SNPs, previously associated with albuminuria-related traits, on albuminuria and renal injury in the UK Biobank population, with a particular interest in diabetes.

Global evidence on falls and subsequent social isolation in older adults: a scoping review.

Background: Falls are a leading cause of injury-related hospitalizations among adults aged 65 years and older and may result in social isolation.

Objective: To summarise evidence on falls and subsequent social isolation and/or loneliness in older adults through a scoping review.

Eligibility Criteria: Studies were eligible for inclusion if the population had a mean age of 60 years or older, they examined falls and subsequent social isolation, loneliness, fear of falling or risk factors and were primary studies (eg, experimental, quasi-experimental, observational and qualitative).

The effects of physical activity on cortisol and sleep: A systematic review and meta-analysis.

Background: Managing stress and having good quality sleep are inter-related factors that are essential for health, and both factors seem to be affected by physical activity. Although there is an established bidirectional relationship between stress and sleep, remarkably few studies have been designed to examine the effects of physical activity on cortisol, a key biomarker for stress, and sleep. Research is particularly scarce in older people despite both sleep and cortisol changing with age.

Interventions for social isolation in older adults who have experienced a fall: a systematic review.

Objectives: The objective of our systematic review was to identify the effective interventions to prevent or mitigate social isolation and/or loneliness in older adults who experienced a fall.

Design: Systematic review.

Data Sources: MEDLINE, Embase, the Cochrane Central Register of Controlled Trials and Ageline were searched (from inception to February 2020).

Utilising social media within incident response programmes.

Humans are social creatures that learn from observing others. Until this century, the reach of social learning was confined to small groups or locales. However, the pervasive adoption of social media platforms has provided the means to augment social learning and empower virtual groups by transcending geographic and time boundaries.

Ready, set, bake: Using the 'Great British Bake Off' to learn important lessons in incidence response.

Adults learn from experiences, be they lived or virtual. In the latter case, television programming offers a variety of opportunities for virtual learning. Indeed, while some people regard 'reality television' as no more than simple entertainment, the manner in which participants tackle complex situations can in fact provide opportunities for learning.

Genetic Strategies to Understand Human Diabetic Nephropathy: In Silico Strategies for Molecular Data-Association Studies.

Multiple genetic strategies are available to help improve understanding of diabetic nephropathy. This chapter provides detailed methodology for a single-nucleotide polymorphism association study and meta-analysis, using a protocol suitable for targeted SNP or genome-wide association studies, to identify genetic risk factors for diabetic nephropathy.

The Challenges of Chromosome Y Analysis and the Implications for Chronic Kidney Disease.

The role of chromosome Y in chronic kidney disease (CKD) remains unknown, as chromosome Y is typically excluded from genetic analysis in CKD. The complex, sex-specific presentation of CKD could be influenced by chromosome Y genetic variation, but there is limited published research available to confirm or reject this hypothesis. Although traditionally thought to be associated with male-specific disease, evidence linking chromosome Y genetic variation to common complex disorders highlights a potential gap in CKD research.

Genetic Susceptibility to Chronic Kidney Disease - Some More Pieces for the Heritability Puzzle.

Chronic kidney disease (CKD) is a major global health problem with an increasing prevalence partly driven by aging population structure. Both genomic and environmental factors contribute to this complex heterogeneous disease. CKD heritability is estimated to be high (30-75%).

Using agility to combat cyber attacks.

Some incident response practitioners feel that they have been locked in a battle with cyber criminals since the popular adoption of the internet. Initially, organisations made great inroads in preventing and containing cyber attacks. In the last few years, however, cyber criminals have become adept at eluding defence security technologies and rapidly modifying their exploit strategies for financial or political gains.

You say you want an evolution (of your risk management programme).

Living organisms must evolve to continue to exist, let alone thrive. This situation is especially true when organisms are faced with a challenging environment, such as the risk management landscape. Risk management organisations need to adopt a continuous adaptation strategy to manage the dynamic threat landscape and build resilience into the risk management function.

The FireWork air quality forecast system with near-real-time biomass burning emissions: Recent developments and evaluation of performance for the 2015 North American wildfire season.

Unlabelled: Environment and Climate Change Canada's FireWork air quality (AQ) forecast system for North America with near-real-time biomass burning emissions has been running experimentally during the Canadian wildfire season since 2013. The system runs twice per day with model initializations at 00 UTC and 12 UTC, and produces numerical AQ forecast guidance with 48-hr lead time. In this work we describe the FireWork system, which incorporates near-real-time biomass burning emissions based on the Canadian Wildland Fire Information System (CWFIS) as an input to the operational Regional Air Quality Deterministic Prediction System (RAQDPS).

The potential and realized spread of wildfires across Canada.

Given that they can burn for weeks or months, wildfires in temperate and boreal forests may become immense (eg., 10(0) - 10(4) km(2) ). However, during the period within which a large fire is 'active', not all days experience weather that is conducive to fire spread; indeed most of the spread occurs on a small proportion (e.

Alanine transaminase rather than abdominal ultrasound alone is an important investigation to justify cholecystectomy in patients presenting with acute pancreatitis.

Objectives: The aims of this study were to investigate the predictive value of an elevated level of alanine transaminase (ALT) for biliary acute pancreatitis (AP) and to reconsider the role of abdominal ultrasound (AUS).

Methods: All patients admitted to Christchurch Public Hospital with AP between July 2005 and December 2008 were identified from a prospectively collected database. Peak ALT within 48 h of presentation was recorded.