High prevalence of cervical intra-epithelial neoplasia in women treated for pelvic inflammatory disease.

Because human papillomavirus (HPV) is sexually transmitted, as are pelvic inflammatory disease (PID) agents, the authors investigated whether cervical intra-epithelial neoplasia (CIN) are more frequent in women under treatment for PID. The study involved 298 patients hospitalized for PID, in whom CIN were investigated by smears and colposcopy. CIN were diagnosed in 42 patients, i.

[Value of screening for cervical intraepithelial neoplasia in women treated for adnexitis].

Objective: To demonstrate that women treated for PID constitute a population with a specially high incidence of cervical intraepithelial neoplasia (CIN) and who should be screened for CIN.

Populations And Methods: Retrospective, non-comparative study of 260 patients treated for PID in the Gynecology-Obstetrics Department of Hôtel-Dieu hospital in Rennes (France) from December 1st, 1989 to May 31st, 1996. CIN screening was performed by smear tests and colposcopy.

[Uterine leiomyosarcoma. Nine case reports, review of the literature].

Object Of The Study: To evaluate management and outcome of the treatment of uterine leiomyosarcoma.

Patients And Methods: Retrospective study of a series of 9 patients treated for uterine leiomyosarcoma in this hospital from 1982 to 1994.

Results: The condition is rarely suspected preoperatively, diagnosis is usually made on histological examination of the operative specimen.

[Müllerian mixed tumors. Experience of the Rennes Regional University Hospital].

Seventeen cases of mixed Muller tumours (tumours of the uterus with malignant epithelial and mesenchymal components) are presented. These recently described tumours are rare and occur in menopaused women. Bloody discharge is the usual clinical manifestation, together with an increase of the volume of the uterus.

[Borderline ovarian tumors. A review and 11 cases].

Objective: To clarify and classify the still debated diagnostic and prognostic elements of borderline tumours of the ovary and analyze the data obtained in our series.

Aim: Develop an adapted management scheme, integrating relatively good prognosis and known or suspected factors of poor prognosis. SIEGE: Department of Gynaecology-Obstetrics, Hôtel-Dieu (CHU) Rennes, France.

[Malignant melanoma of the vagina. Two case reports. Review of the literature].

Objective: Report the diagnosis and therapeutic approach in two cases of primary malignant melanoma of the vagina.

Results: Malignant melanoma is rarely localized in the vagina, resulting from the malignant transformation of an ectopic melanocyte during menopause. The clinical diagnosis is often made in an advanced stage with a variable degree of pigmentation, usually on the anterior aspect of the vagina.

Malignant cystosarcomas phyllodes of the breast in adolescent females.

The authors report a case of cystosarcoma phyllodes occurring in an adolescent female, thus raising to 19 the number of reported cases. The prognosis of those composite fibro-epithelial tumours is ruled by the malignancy of the connective component: the diagnosis shows no distinctive feature compared with what can be observed in adults. The prognosis (classically better) appears in fact totally similar, justifying the same therapeutic rigour, particularly in the surgical field.

[Juvenile ovarian granulosa tumor associated with pregnancy. A case report. Review of the literature].

A case of juvenile tumour of the granulosa occurred in a pregnant woman. Outcome was rapidly fatal. These tumours are classed as mesenchyma tumours of the sexual cords of the ovaries.

[Immature teratoma of the ovary. Apropos of 3 cases. Review of the literature and an evaluation].

Immature teratoma of the ovary is a rare tumour (1% of cancer of the ovary) usually seen in adolescents or young women. It is a malignant tumour derived from an abnormal germ-cell which undergoes meiotic division. The diagnosis is based on the pathological examination which reveals immature tissue derived from two or three types of embryonic tissue (endo-, meso- and ectoderm).

[Primary seropapillary peritoneal carcinoma. 16 case reports. Review of the literature].

Objective: Review of primary seropapillary carcinoma of the peritoneum.

Type Of Study: Retrospective.

Place: Department of Gynaecology and Oncology, University Hospital, Rennes.

[Giant juvenile fibroadenoma in an adolescent. A case report].

Fibroadenomas occupy the first place, in terms of prevalence, among benign breast disorders in adolescent girls. Juvenile giant fibroadenoma is a special though rare form, which must be recognised in terms of differential diagnosis from virginal hyperplasia in its asymmetrical early form and phylloid tumours, the prognosis of which is different. The authors describe the clinical and pathological features necessary for diagnosis and report the results of breast reconstruction after excision via a lateral radial approach in a 14-year-old adolescent girl.

[Breast cancer associated with pregnancy. Nine case reports. Review of the literature and current update].

The authors report nine personal cases in a review of the literature concerning cancers of the breast associated with pregnancy and lactation (until a year post-partum). The diagnosis of the illness is reported to be difficult in pregnant women and it is necessary to use fully all the diagnostic procedures available and in particular cytology and histology. Surgery is urgent.

[Primary pure carcinoid tumor of the breast: a case report. Review of the literature].

The authors present a case of primary pure carcinoid tumour of the breast and point out how rare it is and how they made their diagnosis mainly by histology. A review of the literature makes it possible to assess the prognosis which should be good and they also describe the anatomo-pathological findings in these tumours. Finally these tumours show a strange histogenesis which if it is understood makes it possible to understand certain processes of cellular differentiation in breast tissue.

[Intraductal carcinomas in situ. Retrospective study of 21 cases and review of the literature].

In situ canalicular carcinomas are defined as malignant, galactophoric epithelial cells, do not invade the basal membrane. The author saw 21 cases of in situ canalicular carcinomas which were treated surgically at the University Hospital of Rennes. It is possible from these cases to include certain themes: there is a pathology of an early carcinoma of the breast which will go on growing.

[Circumstances in the detection of carcinoma in situ of the breast. Apropos of 12 cases].

In France, 7,000 women die yearly of cancer of the breast, and 25,000 new cases are registered. The seriousness of the illness and its frequency show how important it is to diagnose it early at a stage before invasion or in situ (where 95 to 100% can be cured). In 4 years, at the University Hospital of Rennes, 90 out of 446 patients who were operated on for breast lesions had invasive cancer of the breast, i.

[Trophoblastic tumor at the site of placental implantation. Apropos of a new case].

The authors report a case in which a trophoblastic tumour developed at the implantation site in a 34-year-old woman in her second pregnancy. She had previously had trophoblastic disease that had persisted after a molar pregnancy. Using monoclonal anti-beta-hCG antibodies in order to localise the tumour by clinical radio immunodetection made it possible to cure the patient.

[Lobular carcinoma in situ of the breast. Apropos of 3 cases].

The authors explain the particular nature of these multifocal tumors: absence of node involvement, difficulties of diagnosis, relatively favorable prognosis and a therapeutic dilemma: limited procedure with strict surveillance, subcutaneous bilateral mastectomy.

[Dynamics of the prolonged and persistent estrogenic endometrium].

Prolonged oestrogenic endometrium and persistent oestrogenic endometrium are frequent pathological states which have in common a variable degree delay or an absence of apparition of histological signs of luteal impregnation. In fact these two main states include several kinds of lesion; in our experience this point of view, which is an artificial division, is a too static one. We have to consider all the possible states to see the evolution of the whole.

[Ovarian goiter. Apropos of a case].

When the authors had a case of ovarian goitre with the Demons-Meigs syndrome they started to look at the literature for the incidence, the clinical presentation, the prognosis and the ways of treating this anatomopathological entity. Although histological examination can rarely make sure that the lesions are benign they are in most cases, as in the remainder of ovarian tumours, so that the outlook should be good.

[Pathology of the umbilical cord].

The pathology of the umbilical cord is an important factor in placental pathology, and may be the cause of acute fetal distress or antenatal death, though many unknown factors still remain.

[Liebow's desquamative interstitial pneumonia. Apropos of a case in an infant].

Case report of a Liebow's desquamative interstitial pneumonia in a 3 week-old infant. The disease resulted in permanent respiratory failure. Steroid therapy had no durable effect and death occurred at 4 1/2 months of age.