Publications by authors named "Kerim Aslan"

Purpose: This study investigates the morphometric changes in the brains of patients with frontal focal cortical dysplasia (FCD) Type II, distinguishing between right and left FCD, using voxel-based morphometry (VBM), surface-based morphometry (SBM), and subcortical shape analysis.

Methods: The study included 53 patients with frontal lobe FCD Type II (28 left-sided, 25 right-sided) and 66 age- and gender-matched healthy controls. VBM and SBM analyses were conducted using Computational Anatomy Toolbox 12.

View Article and Find Full Text PDF

Purpose: To evaluate the diagnostic efficacy of computed diffusion-weighted imaging (DWI) in pediatric posterior fossa tumors generated using high b-values.

Methods: We retrospectively performed our study on 32 pediatric patients who had undergone brain magnetic resonance imaging for a posterior fossa tumor between January 2016 and January 2022. The DWIs were evaluated for each patient by two blinded radiologists.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates microstructural abnormalities in white matter among patients with Behcet's disease (BD) and neuro-Behcet's disease (NBD) using tract-based spatial statistics (TBSS).
  • It includes 43 BD patients without neurological symptoms, 15 NBD patients with normal MRI, and 54 matched healthy controls, analyzing various diffusion metrics.
  • Findings show that both BD and NBD patients had lower fractional anisotropy and higher mean and radial diffusivity in white matter, suggesting issues like impaired fiber integrity and demyelination as potential underlying causes.
View Article and Find Full Text PDF

Unlike somatotroph tumors, the data on correlates of tumor granulation patterns in functional TPIT lineage pituitary neuroendocrine tumors (corticotroph tumors) have been less uniformly documented in most clinical series. This study evaluated characteristics of 41 well-characterized functional corticotroph tumors consisting of 28 densely granulated corticotroph tumors (DGCTs) and 13 sparsely granulated corticotroph tumors (SGCTs) with respect to preoperative clinical and radiological findings, tumor proliferative activity (including mitotic count and Ki-67 labeling index), and postoperative early biochemical remission rates. The median (interquartile range (IQR)) tumor size was significantly larger in the SGCT group [16.

View Article and Find Full Text PDF

Purpose: Transfusion-dependent thalassemia (TDT) is associated with iron accumulation in the body and an increased tendency for thrombosis. With the increased life expectancy in these patients, the detection of neurocognitive complications has gained importance. This study investigates the microstructural changes in TDT patients using advanced diffusion MRI techniques and their relationship with laboratory parameters.

View Article and Find Full Text PDF

Purpose: This study aimed to detect supratentorial cortical and subcortical morphological changes in pediatric patients with infratentorial tumors.

Methods: The study included 24 patients aged 4-18 years who were diagnosed with primary infratentorial tumors and 41 age- and gender-matched healthy controls. Synthetic magnetization-prepared rapid gradient echo images of brain magnetic resonance imaging were generated using deep learning algorithms applied to T2-axial images.

View Article and Find Full Text PDF

Thyroid hormones play a critical role in brain development, but paradoxically, patients with hyperthyroidism often exhibit cognitive decline and irritability. This study aims to explore the pattern of atrophy in hyperthyroid patients, changes in specific areas of the brain, including hypothalamic subfields and limbic structures, and their relationships with hormonal levels and psychometric tests. This prospective cross-sectional study involves 19 newly diagnosed, untreated hyperthyroid patients, and 15 age and gender-matched control subjects.

View Article and Find Full Text PDF

Purpose: Glioblastoma patients develop recurrence in the opposite hemisphere far from the primary tumor site even after complete resection. This is one of the main reasons for short disease survival. Our aim in this study is to detect microstructural changes in the contralateral hemisphere of glioblastoma patients using different diffusion models with the fully automated tract-based spatial statistics (TBSS) method.

View Article and Find Full Text PDF

Background And Purpose: Intracranial tumours in children can exhibit different characteristics compared to those in adults. Understanding the microstructural changes in the contralateral normal-appearing white matter (NAWM) in children with primary intracranial masses is essential for optimizing treatment strategies. This study aimed to investigate the apparent diffusion coefficient (ADC) changes in contralateral NAWM using fully automated methods and deep learning algorithms.

View Article and Find Full Text PDF

Purpose: Multiple sclerosis (MS) is a disease that progresses not only with demyelination but also with neurodegeneration. One of the goals of drug treatment in MS is to prevent neurodegeneration. Cortical thickness (CT), sulcal depth (SD), and local gyrification index (LGI) are indicators related to neurodegeneration.

View Article and Find Full Text PDF

Background And Purpose: Conventional MRI sequences in neuro-oncology are insufficient for glioma grading. However, newly developed diffusion-weighted imaging techniques have been shown to have a great potential for glioma grading. This study examined the diagnostic performance of diffusion tensor imaging (DTI), diffusion kurtosis imaging (DKI), neurite orientation dispersion and density imaging (NODDI), and their combinations in glioma grading.

View Article and Find Full Text PDF

Purpose: Studies on hypothalamic changes in patients with relapsing remitting multiple sclerosis (RRMS) are very scarce, despite the fact that the relationship with the hypothalamus is frequently reported. The aim of the study was to determine the volume of the hypothalamic subunits and the total hypothalamus and its relationship with the total demyelinating lesion volume (TLV) and expanded disability status scale (EDSS) in RRMS patients.

Methods: In this cross-sectional study, anterior-superior, superior tubular, posterior hypothalamus, anterior-inferior, inferior tubular subunits of hypothalamus, and total hypothalamus volume were calculated, with fully automatic analysis methods using volumetric T1 images of 65 relapsed RRMS patients and 68 healthy controls (HC).

View Article and Find Full Text PDF

Purpose: To evaluate the spatial distribution of cortical damage in Behcet's Disease (BD) with or without neurological involvement using a cortical thickness measurement approach using three-dimensional T1-weighted imaging.

Material And Methods: Fifty-eight BD patients without neurological involvement, twenty-two Parenchymal Neuro-Behçets disease (PNBD) patients, and fifty healthy controls were included in the prospective study. Anatomical 3D T1 images were obtained from all participants using 3T MRI.

View Article and Find Full Text PDF
Article Synopsis
  • - The study aimed to determine how the apparent diffusion coefficient (ADC) from diffusion-weighted imaging could help distinguish between small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) brain metastases in patients. - Researchers evaluated ADC values from diffusion-weighted imaging of 158 patients, finding that both the minimum and mean ADC values were significantly lower in SCLC metastases compared to NSCLC metastases, suggesting a possible diagnostic tool. - The results indicated that not only were the ADC values of the metastases lower in SCLC, but the ADC of the surrounding edema was also significantly different, which could aid in better understanding and managing lung cancer brain metastases.
View Article and Find Full Text PDF

Purpose: To determine whether biochemical responses to long-acting forms of first-generation somatostatin analogue (SSA) therapy in patients with acromegaly could be predicted from baseline and postoperative hormone concentrations, and tumor radiological and histopathological characteristics.

Methods: A total of 68 patients with acromegaly for whom postoperative SSA therapy was started were categorized according to their responses to treatment (SSA-responders vs. non-responders).

View Article and Find Full Text PDF

Objectives: This study aimed to investigate the accuracy of conventional Sagittal Turbo spin Echo T2-weighted (Sag TSE-T2W), variable flip angle 3D TSE (VFA-3D-TSE) and high-resolution 3D heavily T2W (HR-3D-HT2W) sequences in the diagnosis of primary aqueductal stenosis (PAS) and Superior Medullary Velum Stenosis (SMV-S), and the effect of stenosis localization on diagnosis.

Methods: Seventy-seven patients were included in the study. The diagnosis accuracy of the HR-3D-HT2W, Sag TSE-T2W and VFA-3D-TSE sequences, was classified into three grades by two experienced neuroradiologists: grade 0 (the sequence has no diagnostic ability), grade 1 (the sequence diagnoses stenosis but does not show focal stenosis itself or membrane formation), and grade 2 (the sequence makes a definitive diagnosis of stenosis and shows focal stenosis itself or membrane formation).

View Article and Find Full Text PDF

Aim: Although radiological methods are sufficient for the diagnosis of spontaneous subarachnoid hemorrhage (SAH), additional biomarkers are needed to predict prognosis. The aim of this study was to investigate the effects of serum S100B protein, Glial Fibrillary Acidic Protein (GFAP) levels and, Optic Nerve Sheath Diameter (ONSD) on mortality and clinical severity in patients with spontaneous SAH.

Materials And Methods: Fifty-six patients who were diagnosed with SAH after first evaluation in the emergency department (ED) were included in the study group; Forty-six patients who were admitted to the ED with headache of non-intracranial etiology, were included as the control group.

View Article and Find Full Text PDF
Article Synopsis
  • Hypothyroidism can lead to various neuropsychiatric issues such as depression and cognitive disorders, prompting research on its impact on white matter integrity in the brain.
  • In this study, 18 patients with hypothyroidism were compared to 14 healthy controls using tract-based spatial statistics (TBSS) to analyze changes in white matter properties through diffusion tensor imaging.
  • Results showed significant reductions in fractional anisotropy (FA) and alterations in diffusivity across several white matter tracts, suggesting that hypothyroidism may cause demyelination that correlates with clinical symptoms like depression.
View Article and Find Full Text PDF
Article Synopsis
  • This study investigates white matter changes in the brains of patients with untreated or newly diagnosed hyperthyroidism using advanced imaging techniques.
  • Researchers compared brain scans of 18 hyperthyroid patients to 14 healthy controls, focusing on various measurements of brain structure.
  • Findings revealed significant increases in radial diffusivity and decreases in axial diffusivity in specific brain regions, suggesting that demyelination may be a key factor in the observed brain dysfunctions associated with hyperthyroidism.
View Article and Find Full Text PDF

Objective: The aim of this study is to assess the microstructural changes to the olfactory bulb (OB) in patients with nasal septum deviation (NSD) using diffusion tensor imaging and to research the association between these changes and the degree of NSD.

Methods: Ninety-six patients with NSD (46 males, 50 females) who received diffusion tensor imaging were assessed by 2 independent readers. The patients were separated into 3 groups according to the NSD angle.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to find out if combining special brain imaging techniques (DWI, MRS, and DSCI) could help doctors tell the difference between two types of brain tumors: high-grade glioma (HGG) and solitary brain metastasis (SBM).
  • They looked at 56 patients who had these imaging tests before their surgeries and compared certain measurements from each imaging technique to see which ones worked best.
  • The best combination of measurements that helped differentiate between HGG and SBM included three specific values, making it a really effective method with a high accuracy score of 0.970.
View Article and Find Full Text PDF

Introduction: As far as we know, left atrium (LA) imaging findings of pre-treatment and post-treatment nonmassive, submassive and massive acute pulmonary embolism (APE) have not been reported in literature. The aim of this study is to assess LA sizes of nonmassive, submassive and massive APE before and after treatment with computed tomography pulmonary angiography (CTPA) and to research whether there are differences between groups.

Materials And Methods: Sixty two adult APE patients (21 nonmassive, 31 submassive and 10 massive) who were diagnosed with CTPA and who had post-treatment follow-up images and recorded clinical information were included in the study.

View Article and Find Full Text PDF

Background/aim: https://orcid.org/0000-0002-9740-3580

Materials And Methods: A total of 404 female patients above 40 years of age who, within a 6-month period, had undergone thoracic computed tomography and mammography for various reasons were screened retrospectively at our clinic. Mammographies were assessed for BAC and thoracic CT investigations were assessed for CAC and AC.

View Article and Find Full Text PDF

The increasing use of mobile phones may have a number of physiological and psychological effects on human health. Many animal and human studies have reported various effects on the central nervous system and cognitive performance from of exposure to electromagnetic fields (EMF) emitted by mobile phones. The aim of the present study was to evaluate the effects of mobile phones on the morphology of the human brain and on cognitive performance using stereological and spectroscopic methods and neurocognitive tests.

View Article and Find Full Text PDF