In silico analysis of potential diagnostic targets from Burkholderia pseudomallei.

Administration of appropriate therapeutic regimes for infections arising from pathogenic species of Burkholderia is critically dependent upon rapid and accurate diagnoses. The purpose of this work is to establish a bioinformatic pipeline to assess protein sequences for their potential as diagnostic targets for the detection of Burkholderia species. Data are presented showing both a bioinformatic methodology for prediction of surface-associated and secreted proteins and its application to a test dataset of proteins from the pathogen B.

Aqueous preparation and physiological stability studies of Re(CO)3(tripodal) compounds.

Re(CO)3L compounds, where L is a methane-derivatized tripodal ligand, can be prepared under aqueous conditions, and one of which displays significant stability under physiological conditions.