Pyrimidine-2,4-dione targets STAT3 signaling pathway to induce cytotoxicity in hepatocellular carcinoma cells.

Signal transducer and activator of transcription 3 (STAT3) is a tumorigenic transcription factor that is persistently activated in various human cancers including hepatocellular carcinoma (HCC). Therefore, STAT3 is considered as a prominent target to counteract the uncontrolled proliferation of cancer cells. In the present report, pyrimidine-2,4-diones (N-methyluracil derivatives) (MNK1-MNK14) were synthesized in an ionic liquid (BMIm PF) medium employing a ligand-free Suzuki-Miyaura cross-coupling process.

The crystal structure of ()-7-chloro-2-(2,5-di-meth-oxy-phen-yl)-2,3-di-hydro-quinazolin-4(1)-one: two hydrogen bonds generate an elegant three-dimensional framework structure.

In the title compound, CHClNO, the heterocyclic ring adopts an envelope conformation, folded across the N⋯N line, with the 2,5-di-meth-oxy-phenyl unit occupying a quasi-axial site. There are two N-H⋯O hydrogen bonds in the structure: one hydrogen bond links mol-ecules related by a 4 screw axis to form a (6) chain, and the other links inversion-related pairs of mol-ecules to form an (8) ring. The ring motif links all of the chains into a continuous three-dimensional framework structure.

Synthesis and antiproliferative effect of novel 4-thiazolidinone-, pyridine- and piperazine-based conjugates on human leukemic cells.

The present work reveals the synthesis and antiproliferative effect of a series of 2, 3 disubstituted 4-thiazolidinone analogues on human leukemic cells. The chemical structures of newly synthesized compounds were confirmed by IR, (1)H NMR, (13)C NMR and mass spectral analysis. Compound methyl 3-methoxy-4-(4-oxo-3-(5-(piperazin-1-yl)pyridin-2-yl)thiazolidin-2-yl)benzoate (5) displayed potent activity (IC509.