Prenatal Nutritional Intervention Reduces Autistic-Like Behavior Rates Among -Deficient Mice.

The causes and contributing factors of autism spectrum disorders (ASD) are poorly understood. One gene associated with increased risk for ASD is methylenetetrahydrofolate-reductase (), which encodes a key enzyme in one carbon (C1) metabolism. The polymorphism reduces the efficiency of methyl group production with possible adverse downstream effects on gene expression.