Publications by authors named "Keren Erez"
Article Synopsis
- The study explores how biological networks, specifically in plant self-incompatibility systems, evolve to prevent self-fertilization through complex molecular interactions between female and male proteins.
- A new theoretical framework is introduced that allows for more interactions between proteins and recognizes the importance of diversity in mating partners, which previous models overlooked.
- The findings reveal that this promiscuity in molecular recognition promotes the formation of different "classes" within the population and indicates potential applications of the framework in other biological systems.
The cancer stem cell (CSC) model suggests that a subpopulation of cells within the tumor, the CSCs, is responsible for cancer relapse and metastasis formation. CSCs hold unique characteristics, such as self-renewal, differentiation abilities, and resistance to chemotherapy, raising the need for discovering drugs that target CSCs. Previously we have found that the antihypertensive drug spironolactone impairs DNA damage response in cancer cells.
View Article and Find Full Text PDFAnalyzing movement trajectories using a Markov bi-clustering method.
J Comput Neurosci
December 2009
In this study we treat scribbling motion as a compositional system in which a limited set of elementary strokes are capable of concatenating amongst themselves in an endless number of combinations, thus producing an unlimited repertoire of complex constructs. We broke the continuous scribblings into small units and then calculated the Markovian transition matrix between the trajectory clusters. The Markov states are grouped in a way that minimizes the loss of mutual information between adjacent strokes.
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