Publications by authors named "Kerem Can Tunc"
Article Synopsis
- The study investigates the effects of pentoxifylline on autism-like behaviors in rat models induced by propionic acid (PPA), focusing on how it influences brain proteins and inflammatory responses.
- Thirty male Wistar albino rats were divided into three groups: a control group, a PPA group, and a PPA plus pentoxifylline group, with various treatment regimens followed by analysis of brain and blood samples.
- Results showed that pentoxifylline significantly reduced autism-like behaviors, lowered levels of the pro-inflammatory cytokine TNF-α, increased beneficial brain factors like ATP and nerve growth factor, and improved neuronal health, suggesting its potential as a neurotherapeutic agent for autism.
Intranasal Insulin Eases Autism in Rats via GDF-15 and Anti-Inflammatory Pathways.
Curr Issues Mol Biol
September 2024
In rat models, it is well-documented that chronic administration of propionic acid (PPA) leads to autism-like behaviors. Although the intranasal (IN) insulin approach is predominantly recognized for its effects on food restriction, it has also been shown to enhance cognitive memory by influencing various proteins, modulating anti-inflammatory pathways in the brain, and reducing signaling molecules such as interleukins. This study seeks to explore the potential therapeutic benefits of IN insulin in a rat model of autism induced by PPA.
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