Epithelial to mesenchymal transition (EMT) in metaplastic breast cancer and phyllodes breast tumors.

Epithelial-mesenchymal transition (EMT), a transdifferentiation program whereby epithelial cells acquire mesenchymal phenotype, is essential during embryonic development. EMT has also been implicated in cancer progression by conferring migratory and metastatic potential, as well as cell plasticity and stem cell like traits, to cancer cells. Metaplastic breast carcinoma (MBC) is a rare aggressive type of breast cancer characterized by the presence of heterologous elements, typically by the existence of epithelial and mesenchymal components.

Cutaneous Side Effects of Modern Targeted Therapy and Immunotherapy in Patients with Dermatological Malignancies.

The advent of immunotherapy and targeted therapies in treating dermatological malignancies has dramatically changed the landscape of dermato-oncology in recent years. Their superior efficacy compared to previous therapeutic options, such as chemotherapy, has resulted in their use in treating devastating malignancies, such as melanoma or unresectable/metastatic basal cell and squamous cell carcinoma. Skin toxicity is a critical safety consideration, among other adverse reactions, that can occur under treatment with these agents.

Nipple candidiasis and painful lactation: an updated overview.

Nipple pain and discomfort during or after breastfeeding remains one of the most common reasons for premature cessation of lactation among the affected women. The belief that yeasts, and especially spp., are responsible for such symptoms is highly supported by many physicians, midwives, or lactation specialists, but is also viewed with scepticism by other health care providers.

Management of Pediatric Nail Psoriasis.

Nail psoriasis is a condition that can affect children and adolescents. It often is refractory to treatment. Data on its management in the pediatric population are limited.

Successful treatment of a keratoacanthoma in a young patient with the application of topical 5% imiquimod cream.

Keratoacanthomas (KA) are epithelial tumors that present as rapidly evolving nodules with a central hyperkeratotic plug and occasionally show signs of spontaneous regression. A 21-year-old patient strongly refused the diagnostic biopsy and insisted on a nonsurgical treatment. He was successfully treated with imiquimod 5% cream.

Comparison of intra-abdominal abscess formation after laparoscopic and open appendectomy for complicated and uncomplicated appendicitis: a retrospective study.

Introduction: Acute appendicitis (AA) is one of the most common causes of acute abdominal pain seen in emergency departments and appendectomy has been the preferred treatment of this disease for decades. Postoperative intra-abdominal abscess (PIAA) complicates 3% to 25% of appendectomies and the risk is highest following complicated appendicitis. However, the risk for intra-abdominal abscess formation after appendectomy is still a matter of debate.

A deep-learning-based prediction model for the biodistribution of Y microspheres in liver radioembolization.

Background: Radioembolization with Y microspheres is a treatment approach for liver cancer. Currently, employed dosimetric calculations exhibit low accuracy, lacking consideration of individual patient, and tissue characteristics.

Purpose: The purpose of the present study was to employ deep learning (DL) algorithms to differentiate patterns of pretreatment distribution of Tc-macroaggregated albumin on SPECT/CT and post-treatment distribution of Y microspheres on PET/CT and to accurately predict how the Y-microspheres will be distributed in the liver tissue by radioembolization therapy.

Green nail syndrome caused by .

A 34-year-old woman presented due to progressive painful swelling around the nail of the right index finger. Onychectomy and drainage of the abscess of the affected finger were performed as the inflammation was progressive despite the previous antibiotic therapy. The microbiological culture revealed a ciprofloxacin-susceptible Citrobacter braakii.

Primary Burkitt lymphoma of the thyroid gland in a 28-year-old female.

Not required for Clinical Vignette.

On- and Off-Label Uses of Apremilast in Dermatology.

Apremilast is an oral small-molecule phosphodiesterase 4 inhibitor with a multilevel immunomodulating mechanism of action. It has received approval in many countries for the use in moderate-to-severe plaque psoriasis and active psoriatic arthritis in adults. Herein, we review the literature concerning the use of apremilast in dermatology, with a focus on both the on- and the off-label uses of this medication in dermatologic conditions.

The Impact of COVID-19 on the Life Quality of Ambulatory Patients With Chronic Skin Conditions.

This article addresses the issue of the psychological distress of ambulatory dermatologic patients on the ground of cancelation of nonurgent dermatology visits during the SARS-CoV-2 pandemic, as well as the risk of underestimating the emotional suffering of patients with chronic skin diseases, which traditionally would not qualify as urgent cases.

Dupilumab in pediatric dermatology.

Background: Dupilumab is a monoclonal antibody that targets the interleukin (IL)-4 receptor alpha subunit of the IL-4 and IL-13 receptor. This novel agent has received a license for the treatment of moderate-to-severe atopic dermatitis in patients aged ≥12 years. However, data on the dupilumab use in the pediatric population are still extremely limited.

Paraneoplastic erythroderma: an insight on the existing data.

Exfoliative erythroderma is a severe dermatologic condition with variable underlying causes. The association of erythroderma with an occult visceral malignancy is a relatively uncommon finding, which, however, can be accompanied by devastating consequences. This report is the first updated overview regarding the latest data on paraneoplastic erythroderma and was conducted according to the PRISMA Guidelines for systematic reviews.