Neurotoxicity of nitrous oxide: multimodal evoked potentials in an abuser.

Introduction: Nitrous oxide (N2O) damages the nervous system of chronic abusers. Multimodal evoked potentials (EPs) can help document the electrophysiological abnormalities of N2O abusers and its distribution in the nervous system.

Case Report: A 41-year-old male N2O abuser had used N2O (4-5 cans/per day, about 2000 ml/can) for more than 10 years.

Median nerve motor conduction velocity is concordant with myelin protein zero gene mutation.

Background: Myelin protein zero gene (MPZ) mutations may account for a small proportion of cases of Charcot-Marie-Tooth disease (CMT). Different MPZ mutations may be associated with different clinical and electrophysiological phenotypes.

Objectives: To expand our understanding of the characteristics of nerve conduction velocity (NCV) in patients with different MPZ mutations, the authors collected and analysed the NCV values from patients with MPZ mutations.

Myelin protein zero gene mutations in Taiwanese patients with Charcot-Marie-Tooth disease type 1.

Background: Charcot-Marie-Tooth disease type 1 (CMT1) is the most common inherited peripheral neuropathy and represents a genetically heterogeneous condition. In addition to the peripheral myelin protein 22 gene (PMP22) duplication (CMT1A), myelin protein zero gene (MPZ) mutations may account for a certain portion of CMT1 patients (CMT1B).

Objectives: The authors analyzed the MPZ mutations in Taiwanese patients who do not have PMP22 duplication.