Influence of Intraoperative Pain Management on Postoperative Delirium in Elderly Patients: A Prospective Single-Center Randomized Controlled Trial.

Introduction: Intraoperative analgesia and sedation are closely related to postoperative delirium. Depth of sedation based on bispectral index (BIS) guidance has been shown to reduce the occurrence of postoperative delirium (POD). However, the correlation between intraoperative analgesia levels and POD is unclear.

ZLN005 Reduces Neuroinflammation and Improves Mitochondrial Function in Mice with Perioperative Neurocognitive Disorders.

Background: The decrease expression of PGC-1α contributes to perioperative neurocognitive disorders (PND). This study aimed to investigate the effects of the PGC-1α agonist ZLN005 in preventing PND and to explore the potential mechanism.

Methods: C57BL/6 mice were randomly divided into four groups: the control group (Group C), the surgery group (Group S), the surgery and ZLN005 (5 mg/(kg⋅d)) group (Group L), and the surgery and ZLN005 (7.

Effects of different anesthetic regimens on postoperative cognitive function of elderly patients undergoing thoracic surgery: a double-blinded randomized controlled trial.

Objective: Postoperative cognitive dysfunction (POCD) is a serious surgical complication. We assessed the different POCD incidences between anesthesia using sevoflurane and sevoflurane combined with dexmedetomidine, with propofol-based sedation in elderly patients who underwent a thoracic surgical procedure.

Methods: A total of 90 patients aged 65 to 80 years old who underwent a thoracic surgical procedure at our hospital and 15 nonsurgical participants as controls, were enrolled in this study.

Cholesterol Metabolism in Neurodegenerative Diseases.

Cholesterol plays a crucial role in the brain, where it is highly concentrated and tightly regulated to support normal brain functions. It serves as a vital component of cell membranes, ensuring their integrity, and acts as a key regulator of various brain processes. Dysregulation of cholesterol metabolism in the brain has been linked to impaired brain function and the onset of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease, and Huntington's disease.

Remifentanil is Superior to Propofol for Treating Emergence Agitation in Adults After General Anesthesia.

Background: Emergence agitation (EA) is one of the most common complications in clinical general anesthesia during recovery in adults. Remifentanil and propofol can reduce the incidence of EA, but with no randomized controlled trial to evaluate their effectiveness for treating EA. This study aims to compare the effectiveness of remifentanil and propofol for treating EA following general anesthesia.

Alginate-Xylan Biopolymer as a Multifunctional Binder for 5 V High-Voltage LNMO Electrodes.

LiNiMnO (LNMO) with a spinel structure is one of the most promising cathode materials choices for Li-ion batteries (LIBs). However, at a high operating voltages, the decomposition of organic electrolytes and the dissolution of transition metals, especially Mn(II) ions, cause unsatisfactory cycle stability. The initial application of a sodium alginate (SA)-xylan biopolymer as an aqueous binder aims to address the aforementioned problems.

Principle of relationship between seepage movement and action.

The seepage is completed under the control of the action. There is a definite relationship between the seepage and its controlling factors. The recharge flow, seepage flow and water level change are unified.

Dose Selection of Ropivacaine for Spinal Anesthesia in Elderly Patients with Hip Fracture: An Up-Down Sequential Allocation Study.

Objective: The dose selection of ropivacaine for spinal anesthesia in clinical work mainly depends on the experience of the anesthesiologist. In this study, a prospective and modified up-down sequential allocation design was used to provide the optimal dose selection of ropivacaine for spinal anesthesia.

Patients And Methods: This study was divided into two stages, and a total of 164 elderly patients with elective hip fractures were included.

Analysis of stability law and optimization of slope angle during excavation of deep concave mine slope.

Occasional collapse failure is a typical occurrence during mine slope excavation processes. This study aimed to investigate the disaster law in the process of mining slope excavation, and further explore the optimal selection of excavation angle. Based on the systematic analysis of the residual sliding force and deformation response characteristics during slope excavation, the increment of the residual sliding force increases and the stability coefficient decreases with the increase in excavation depth.

What is the impact of perioperative cerebral oxygen desaturation on postoperative delirium in old population: a systemic review and meta-analysis.

Background: Perioperative cerebral oxygen saturation (ScO) has been reported to associate with postoperative delirium (POD) which is a common postoperative complication, however, the results were inconclusive. Therefore, we aimed to conduct an up-to-date review and meta-analyze the relationship between perioperative ScO and POD.

Methods: We systematically searched PubMed, Embase and Web of science through January 13, 2022.

Hippocampus-Based Mitochondrial Respiratory Function Decline Is Responsible for Perioperative Neurocognitive Disorders.

Perioperative neurocognitive disorders (PNDs) are a type of cognitive dysfunction occurring with a higher incidence in elderly patients. However, the pathological mechanism of PND and effective treatment remain elusive. We generated a PND mouse model by providing wild-type mice with surgical trauma; in our case, we used tibial fracture to investigate PND pathology.

Comparison of the innovative endoscopic oropharyngeal airway and the conventional mouthpiece in elderly outpatients undergoing esophagogastroduodenoscopy under sedation: a prospective and randomized study.

Background: Undesirable outcomes may appear for elderly patients undergoing esophagogastroduodenoscopy (EGD) under sedation, such as hypoxia and hypotension. The aim of our study was to investigate the ability of the innovative endoscopic oropharyngeal airway to reduce the frequency of hypoxia during EGD under sedation in elderly patients.

Methods: In this trial, aged patients undergoing EGD were randomized into airway group and mouthpiece group.

Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing.

Background: Aberrant alternative splicing plays critical role in aging and age-related diseases. Heterogeneous nuclear ribonucleoproteins (hnRNPs) reportedly regulate RNA splicing process. Whether and how hnRNPs contribute to age-related neurodegenerative diseases, especially Alzheimer's disease (AD), remain elusive.

The meso-fracturing mechanism of marble under unloading confining pressure paths and constant axial stress.

Failure tests on marble during unloading confining-pressure under constant axial stress and simulations with the particle flow code were performed. The influence mechanism of the unloading rate of the confining pressure, initial unloading stress, and confining pressure on the failure characteristics of, and crack propagation in, marble was studied. By using the trial-and-error method, the conversion relationship between the unloading rates of confining pressures in laboratory tests and numerical simulations was ascertained.

Effects of sliding liquefaction on homogeneous loess landslides in western China.

Sliding liquefaction is considered to be the cause of high-speed and long-distance sliding of some homogeneous loess landslides in western China. However, there is still a lack of necessary experimental research and analysis on the effects of sliding liquefaction on these landslides. In this work, the effects of sliding liquefaction on irrigation-induced, high-speed and long-distance loess landslides on the South Jingyang Tableland area in China are studied by performing large-scale ring shear tests and using the sled mode.

A Wide Bandgap Polymer Donor Composed of Benzodithiophene and Oxime-Substituted Thiophene for High-Performance Organic Solar Cells.

Oxime-substituted thiophene (TO) is used as an acceptor (A) unit to copolymerize with the benzodithiophene (BDT) donor (D) unit to form a novel D-A polymer donor, PBDTTO, which has a low-lying highest occupied molecular orbital energy level () of -5.60 eV and a wide bandgap of 2.03 eV, forming complementary absorption and matching energy levels with the narrow bandgap nonfullerene acceptors.

Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.

Astrocytes metabolically interact with neighboring neurons by providing multiple substances to neurons. How astrocytes regulate neural functions via altering the neuronal metabolic state remains elusive. Here, we demonstrate that astrocytic ApoE vectors a variety of microRNAs (miRNAs), and these miRNAs specifically silence genes involved in neuronal cholesterol biosynthesis, ultimately accounting for accumulation of the pathway-initiating substrate acetyl-CoA.

Synthesis of Poly(bisisoindigo) Using a Metal-Free Aldol Polymerization for Thin-Film Transistor Applications.

Typical syntheses of conjugated polymers rely heavily on organometallic reagents and metal-catalyzed cross-coupling reactions. Here, we show that an environmentally benign aldol polymerization can be used to synthesize poly(bisisoindigo), an analog of polyisoindigo with a ring-fused structural repeat unit. Owing to its extended conjugation length, poly(bisisoindigo) absorbs across the UV/vis/NIR spectrum, with an absorption tail that reaches 1000 nm.

Astragaloside IV prevents kidney injury caused by iatrogenic hyperinsulinemia in a streptozotocin‑induced diabetic rat model.

Diabetic patients are able to manage their blood glucose with exogenous insulin but, ultimately, remain at risk of diabetic nephropathy (DN). Long‑term use of insulin may lead to iatrogenic hyperinsulinemia, which has been suggested to cause kidney injury. However, there are no effective interventions for iatrogenic hyperinsulinemia leading to kidney damage.

Asymmetric Conjugated Molecules Based on [1]Benzothieno[3,2-b][1]benzothiophene for High-Mobility Organic Thin-Film Transistors: Influence of Alkyl Chain Length.

Herein, we report the synthesis and characterization of a series of [1]benzothieno[3,2-b][1]benzothiophene (BTBT)-based asymmetric conjugated molecules, that is, 2-(5-alkylthiophen-2-yl)[1]benzothieno[3,2-b][1]benzothiophene (BTBT-Tn, in which T and n represent thiophene and the number of carbons in the alkyl group, respectively). All of the molecules with n ≥ 4 show mesomorphism and display smectic A, smectic B (n = 4), or smectic E (n > 4) phases and then crystalline phases in succession upon cooling from the isotropic state. Alkyl chain length has a noticeable influence on the microstructures of vacuum-deposited films and therefore on the performance of the organic thin-film transistors (OTFTs).

Propofol in combination with remifentanil for cesarean section: Placental transfer and effect on mothers and newborns at different induction to delivery intervals.

Objective: This study aims to describe the administration of propofol in combination with remifentanil for the induction of general anesthesia during cesarean section (CS). Our aim was to evaluate its impact on the drug concentrations of the maternal and neonatal blood at different induction of anesthesia to delivery (I-D) intervals as well as its effect on newborns.

Materials And Methods: In this double-blind randomized controlled study, patients undergoing elective CS were administered anesthesia at short (n = 20) or long (n = 20) I-D intervals.

Treatment of acute gouty arthritis by blood-letting cupping plus herbal medicine.

Objective: To observe the therapeutic effect of blood-letting cupping plus herbal medicine for acute gouty arthritis.

Methods: The 34 cases of acute gouty arthritis were treated by blood-letting cupping plus herbal medicine.

Results: 21 cases were cured and 13 cases improved.