Publications by authors named "Keqi Zeng"
Article Synopsis
- - Recent studies highlight the role of sphingolipids and the PI3K-Akt signaling pathway in ischemic stroke, with S1P activating this pathway for protective effects, while Buyang Huanwu Decoction (BHD) is a traditional treatment with unclear mechanisms related to this pathway.
- - The study aimed to explore BHD's mechanism of action against ischemic stroke through the S1P/S1PR1/PI3K/Akt pathway, using a mouse model and comparing various treatment groups over a 14-day period.
- - Results showed that both BHD and Calycosin improved neurological scores and reduced infarct volumes, indicating their potential efficacy in treating ischemic stroke by enhancing specific protein
Article Synopsis
- * Using a reliable LC-MS/MS method, the study measures sphingolipid levels in rat serum and brain tissue, noting significant increases in certain sphingolipids after inducing stroke, while one component decreased.
- * The conclusion highlights the potential of this innovative method to identify lipid biomarkers for cerebral ischemia, aiding in stroke assessment and management.
Objective: To conduct a comparative study on the brain pharmacokinetics of seven ingredients (i. e. senkyunolide A, ferulic acid, formononetin, calycosin, ononin, calycosin----glucopyranoside, and paeoniflorin), which were the compounds of Buyang Huanwu Decoction (BHD), in normal and cerebral ischemia rats administrated intragastrically with BHD.
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