Permeability and Porosity of Artificial-Similar Material for Biomimetic Geotechnical Engineering via Direct Ink Writing for Sustainability.

Direct ink writing of multiple mineral materials (M) coupled with simulation analysis is an optimization solution in accordance with low-carbon and sustainable manufacturing. It improves the ability to imitate natural biological iterative optimization, and accurately obtained data for geological model tests to effectively help prevent natural disasters. This article investigates the effects of equivalent materials on the direct ink writing and permeability behaviors through geological simulation models.

Effect of hydroxychloroquine on pregnancy outcome in patients with SLE: a systematic review and meta-analysis.

Objective: Hydroxychloroquine (HCQ) is an antimalarial drug employed in the treatment of systemic lupus erythematosus (SLE). Prior studies reported inconsistent results regarding the association between HCQ use during pregnancy and adverse pregnancy outcomes. This study aimed to evaluate the impact of HCQ on pregnancy-related outcomes in women with SLE.

Integrated Analysis Identifies Upregulated SAMD9L as a Potential Biomarker Correlating with the Severity of Primary Sjögren's Syndrome.

Background: Primary Sjögren's syndrome (pSS) is an autoimmune disease with lymphocytic infiltration of the salivary and lachrymal glands, whose present disease-specific objective indicators are few and have shortcomings that should be addressed. An integrated analysis of sequencing data from different cohorts has the potential to unveil novel biomarkers in pSS.

Methods: We identified 3 GEO datasets, including gene expression data from minor salivary gland (MSG) biopsy samples of 49 patients with pSS and 31 non-pSS and whole blood cells of 30 pSS patients and 30 healthy controls (HCs).

Protocol for rheumatoid arthritis complicated with cardiovascular damage treated with Guanxining tablet with a randomized controlled trial.

Background: Cardiovascular disease (CVD) is the main cause of death in patients with rheumatoid arthritis (RA). Apart from traditional cardiovascular risk factors, immune dysfunction and chronic inflammation of RA are also risk factors for complex cardiovascular damage. Although methotrexate (MTX) is beneficial to CVD in RA patients by inhibiting inflammation, its adverse effects limit its clinical application.

Assessment of bidirectional relationships between systemic lupus erythematosus and anxiety disorder: A two-sample Mendelian randomization study.

Background: Observational studies have demonstrated that there was a significant correlation between systemic lupus erythematosus (SLE) and anxiety disorder, but the causal relationship between them is not so clearly established. This study aims to reveal the potential causal link between SLE and anxiety disorder.

Methods: Summary statistical data of SLE and anxiety disorder were from two large-scale genome-wide association studies (GWAS) of European ancestry, followed by a bidirectional two-sample Mendelian randomization (MR) analysis.

Assessment of bidirectional relationships between depression and rheumatoid arthritis among adults: a two-sample Mendelian randomization study.

Objective: Increasing evidence shows that depression is associated with rheumatoid arthritis (RA). However, the causality and direction of this association remain unclear, because links between the two diseases might be caused by shared environmental confounding factors. Our study aims to understand a putative causal link between the two diseases.

Design, Synthesis, and Antitumor Evaluation of Novel Mono-Carbonyl Curcumin Analogs in Hepatocellular Carcinoma Cell.

Curcumin is a polyphenolic natural product that has promising anticancer properties. However, its clinical utility is limited by its chemical instability and poor metabolic properties. In this paper, a series of new curcumin analogs were synthesized and found to be potent antiproliferative agents against the HepG2 cell line by MTT assay.

Safety of COVID-19 vaccines in patients with non-communicable diseases: a protocol for systematic review and meta-analysis of randomised controlled trials.

Introduction: The COVID-19 global pandemic has posed enormous threats to public health around the world. Vaccines are considered the best therapeutic strategy against the COVID-19 pandemic. However, the adverse reactions of vaccines significantly affect the rates of vaccination and may be more serious in patients with non-communicable diseases (NCDs).

Lianhua Qingwen Capsules Reduced the Rate of Severity in Patients with COVID-19: A System Review and Meta-Analysis of Randomized Controlled Trials.

Background: The rate of severity is a critical factor affecting the prognosis and mortality in coronavirus disease 2019 (COVID-19). Lianhua Qingwen capsules or granules (LQ) have been a promising Chinese patent medicine in treating infectious diseases and recommended for treating COVID-19. This meta-analysis aims to demonstrate the association between LQ treatment and the rate of severity in patients with mild or moderate COVID-19.

Aflatoxin B1: metabolism, toxicology, and its involvement in oxidative stress and cancer development.

Aflatoxins are a class of carcinogenic mycotoxins produced by fungi, which are widely distributed in nature. Aflatoxin B1 (AFB1) is the most toxic of these compounds and its metabolites have a variety of biological activities, including acute toxicity, teratogenicity, mutagenicity and carcinogenicity, which has been well-characterized to lead to the development of hepatocellular carcinoma (HCC) in humans and animals. This review focuses on the metabolism of AFB1, including epoxidation and DNA adduction, as it concerns the initiation of cancer and the underlying mechanisms.

Association of polymorphisms and the single nucleotide polymorphism rs2243188 with systemic lupus erythematosus.

Objective: Abnormal B cell lymphoma-2 (Bcl-2) and interleukin-19 (IL-19) expression is closely related to systemic lupus erythematosus (SLE) pathogenesis. We aimed to determine whether polymorphisms and a single nucleotide polymorphism (SNP) of are significantly associated with SLE susceptibility and if this is affected by synergism between and genotypes.

Methods: This observational cohort study randomly enrolled 150 patients with SLE and 150 healthy controls.

The combined therapy of fecal microbiota transplantation and laxatives for functional constipation in adults: A systematic review and meta-analysis of randomized controlled trials.

Objective: Functional constipation is a prevalent, burdensome gastrointestinal disorder whose treatment remains challenging. Combined therapy uniting multiple treatments may be promising. Fecal microbiota transplantation (FMT) which tends to be an etiological treatment has been increasingly investigated in its management.

An overview of autophagy: Mechanism, regulation and research progress.

Autophagy refers to the formation of autophagosomes by membrane wrapping part of the cytoplasm and the organelles and proteins that need to be degraded in the cells. Autophagosomes are fused with lysosomes to form autophagolysosome, which degrade the contents of the inclusions, to achieve cell homeostasis and organelle renewal. The regulatory mechanism of autophagy is complex, and its upstream signaling pathway mainly involves mTOR dependent pathway and mTOR independent pathway (AMPK, PI3K, Ras-MAPK, p53, PTEN, endoplasmic reticulum stress).

The influence mechanism of nano-alumina content in semi-solid ceramic precursor fluid on the forming performance a light-cured 3D printing method.

The use of three-dimensional (3D) printing technology to form ceramic materials can greatly reduce the technical difficulty and cost of preparing special-shaped ceramic parts. In this work, the formation of the 3D structure of ceramic products was achieved through light-curing 3D printing technology. The semi-solid ceramic precursor fluid prepared from nano alumina particles (AlO), photocurable polyurethane acrylate (PUA) and isobornyl methacrylate (IBOMA) resin was used to realize ceramic fluid with self-made light-curing 3D printing equipment.