Publications by authors named "Keolebogile N Mmasa"

Few studies have evaluated postpartum depression (PPD) in women living with HIV (WLHIV) in Botswana, a high prevalence HIV setting. The Edinburgh Postnatal Depression Scale (EPDS) was used to evaluate PPD symptoms in WLHIV ( = 300) and women who are HIV-uninfected ( = 131) in the Tshilo Dikotla study, an observational cohort study with a nested randomized trial. The EPDS was administered at 2, 6, and 12 months postpartum.

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Background: There are little data on changes in insulin sensitivity during the first few years of life following in utero human immunodeficiency virus (HIV) and antiretroviral (ARV) exposure.

Methods: The Tshilo Dikotla study enrolled pregnant persons with HIV (PWH) (receiving tenofovir/emtricitabine or lamivudine plus dolutegravir or efavirenz) and pregnant individuals without HIV, as well as their liveborn children. Newborns were randomized to receive either zidovudine (AZT) or nevirapine (NVP) postnatal prophylaxis.

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Background: Few data exist on early-life metabolic perturbations in newborns with perinatal HIV and antiretroviral (ARV) exposure but uninfected (HEU) compared to those perinatally HIV unexposed and uninfected (HUU).

Methods: We enrolled pregnant persons with HIV (PWH) receiving tenofovir (TDF)/emtricitabine or lamivudine (XTC) plus dolutegravir (DTG) or efavirenz (EFV), and pregnant individuals without HIV, as well as their liveborn infants. Newborns were randomized to receive either zidovudine (AZT) or nevirapine (NVP) postnatal prophylaxis.

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Synopsis of recent research by authors named "Keolebogile N Mmasa"

  • - Keolebogile N Mmasa's research primarily investigates the health implications of HIV exposure in both mothers and children, focusing particularly on postpartum depressive symptoms and insulin sensitivity in Botswana, a region with high HIV prevalence.
  • - In a recent study, Mmasa found that maternal HIV status is associated with increased postpartum depressive symptoms, utilizing the Edinburgh Postnatal Depression Scale to assess affected populations over a year after childbirth.
  • - Additional findings indicate that newborns exposed to HIV in utero, regardless of their HIV status, show reduced insulin sensitivity compared to those not exposed, highlighting potential early-life metabolic issues associated with antiretroviral medication.

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