Publications by authors named "Kenzo Takahashi"
Article Synopsis
- Extramammary Paget disease (EMPD) is a rare skin cancer often treated with surgery, but some patients don't respond well to chemotherapy, especially those who become resistant to trastuzumab, a drug targeting HER2.* -
- Researchers created patient-derived xenografts (PDX) that mimic the traits of EMPD, finding that trastuzumab resistance was linked to the loss of the PTEN gene, which affects cell growth signaling.* -
- The study shows that using PTEN inhibitors can help restore sensitivity to trastuzumab, and the TR EMPD-PDX models responded well to other targeted therapies and chemotherapy, indicating new treatment possibilities.*
Article Synopsis
- Children, newborns, and pregnant or postpartum women are particularly vulnerable to disasters, making support for this population crucial, especially in disaster-prone areas like Japan.
- The Disaster Liaison for Pediatric and Perinatal Medicine (DLPPM) is a system designed to specifically address the needs of this group and includes lessons on improving emergency response efforts.
- Key lessons from DLPPM's activities suggest the importance of broadening support systems, mitigating the indirect impacts of disasters, and enhancing networking among healthcare facilities to better serve pediatric and perinatal needs during emergencies.
Article Synopsis
- * A study in Kita Ward, Tokyo involved semi-structured interviews to identify challenges in discharge support, including disparities in perspectives, worker competencies, elderly self-reliance, family dependency, and payment system impacts.
- * Proposed solutions emphasize enhancing community connections at the local level, but there's a need for broader examination of these issues at national and prefectural levels to align solutions with policy goals.
In the implementation of the policy for the elderly, the nurses who have the competency to pull out their potential power to continue living with several stakeholders' support are required to provide care in the community. Community nurse in Thailand has the responsibility to deliver adequate medical care and also social care for the elderly. The study aimed to identify the role of community nurse in the implementation of Thai health policy for the elderly.
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- - The study focuses on understanding how gene expression is regulated in response to biological stimuli, requiring the synthesis of nascent RNA and translation to produce functional proteins.
- - A new method called P-stalk-mediated TRAP (P-TRAP) was developed to simultaneously measure nascent RNA synthesis and translation at the gene level, which is typically challenging due to limited existing techniques.
- - The effectiveness of this method was validated in mammalian cells, showing it can analyze the changes in RNA synthesis and translation during conditions like the unfolded protein response in the endoplasmic reticulum, making it a valuable tool for analyzing gene regulation across eukaryotes.
Article Synopsis
- The study aimed to understand how adverse reactions from COVID-19 vaccinations affect immune responses, focusing on the second and third doses of the vaccine in a large cohort in Japan.
- Researchers analyzed data from 2,198 participants who received either the Pfizer or Moderna vaccine, looking at their immune levels and reported adverse reactions.
- Findings showed that participants with more systemic adverse reactions after vaccinations had stronger immune responses, indicating that these reactions could enhance overall immunity and potentially encourage more people to receive a third vaccine.
Article Synopsis
- * A postmarketing surveillance study, which involved 83 participants over 52 weeks, evaluated the drug's safety and effectiveness in real-world settings, focusing on adverse drug reactions (ADRs) and clinical outcomes.
- * Findings showed that 62.8% of patients achieved significant clinical response after a year, with a manageable safety profile; however, there was one serious adverse event leading to a fatality due to liver disorder.
Article Synopsis
- Early initiation of breastfeeding (EIBF) is crucial for lowering neonatal and infant mortality, especially in Sub-Saharan Africa, where both rates are high and EIBF prevalence is low.
- A scoping review conducted from 2008 to 2021 identified key factors influencing EIBF, categorized into household, maternal, and health service characteristics, highlighting that cesarean sections can delay breastfeeding initiation.
- Only eleven studies focused on EIBF in Central and West Africa were found, indicating a need for more research to address geographic gaps and explore effective interventions for women after cesarean deliveries.
This is the English version of Japanese guidance for the use of oral Janus kinase (JAK) inhibitors (JAK1 and tyrosine kinase 2 [TYK2] inhibitors) in the treatments of psoriasis. Several cytokines, such as interleukin (IL)-6, IL-7, IL-12, IL-21, IL-22, IL-23, interferon (IFN)-α, and IFN-γ, are involved in the pathogenesis of psoriasis (including psoriatic arthritis). As oral JAK inhibitors hinder the JAK-signal transducers and activators of transcription signal transduction routes involved in the signal transduction of these cytokines, they may be effective for the treatment of psoriasis.
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- Adult T-cell leukemia/lymphoma (ATLL) is a type of T-cell cancer linked to the HTLV-1 virus, characterized by specific immunophenotypes outlined by the 2017 WHO classification which includes several positive and negative markers.
- A study assessing immunohistochemical profiles in 117 ATLL cases revealed that 20% did not fit the typical immunophenotype, with significant findings such as high rates of TCR negativity and associations between specific markers and morphological characteristics.
- No single immunophenotypic marker was found to be predictive of overall survival in ATLL patients, highlighting the complexity of the disease and the need for further research into its diverse profiles.
Purpose: Since 2020, the novel coronavirus infection (COVID-19) has spread globally. A few studies have investigated the safety of COVID-19 convalescent plasma (CCP) apheresis from COVID-19. This study was the first retrospective observational study of CCP in Japan.
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