Publications by authors named "Kentaro Matsuishi"
Lung adenocarcinoma has never before been reported to be associated with von Hippel-Lindau (VHL) disease. Here, we report a case of VHL disease in a patient who had metachronous multiple lung adenocarcinomas. The patient is a 64-year-old-woman with VHL disease.
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- Advances in high-resolution CT have led to a rise in the detection of multiple lung adenocarcinomas, prompting a study on the genetic background of these tumors, specifically focusing on SNPs in the CYP19A1 gene.
- The study analyzed 51 cases of multiple adenocarcinomas, 62 cases of single adenocarcinoma, and 126 control cases using a TaqMan assay and RT-PCR for gene expression.
- Findings show that the minor allele of SNP rs3764221 in the CYP19A1 gene is significantly linked to an increased risk of multiple adenocarcinomas and is associated with higher CYP19A1 mRNA expression levels.