Publications by authors named "Kentaro Inoue"
Article Synopsis
- The study examines how bariatric/metabolic surgery affects the incidence and severity of COVID-19 among patients in Japan, amidst ongoing debates about its protective benefits.
- Data were collected from 83 institutions, revealing that while there were no severe cases or deaths among 119 patients studied, moderate COVID-19 cases were notably more prevalent in these bariatric patients than in the general population.
- The findings suggest that bariatric/metabolic surgery does not reduce the risk of COVID-19 complications, as moderate cases were linked to specific risk factors such as dyslipidemia and prior infection.
Article Synopsis
- * A retrospective analysis of 230 patients showed that those with spontaneous IMA occlusion experienced lower rates of sac enlargement and higher freedom from re-intervention compared to those with a patent IMA or type II endoleak.
- * Key predictors for spontaneous IMA occlusion include lack of antiplatelet therapy, higher pre-operative hematocrit, and other specific anatomical conditions; patients with more predictors had significantly higher occlusion rates.
Article Synopsis
- This study examines how various muscle strengths and tongue pressure relate to exercise capacity in patients with oesophageal cancer, aiming to improve preoperative management through targeted prehabilitation strategies.
- Data from 29 patients showed significant links between respiratory muscle strength and handgrip/lower limb strength, while tongue pressure did not correlate with these strengths but was related to dysphagia and nutritional status.
- The findings suggest that effective prehabilitation should include exercise, nutritional support, and swallowing training, particularly for patients struggling with food intake, as indicated by tongue pressure assessments.
Background: To examine the influence of liver function on patients with chronic limb-threatening ischemia (CLTI), we classified patients with CLTI after revascularization according to their modified albumin-bilirubin (ALBI) grades.
Methods: We retrospectively analyzed single-center data of patients who underwent revascularization for CLTI between 2015 and 2020. Patients were classified with ALBI grades 1, 2a, and 2b and 3 according to the ALBI score, which was calculated, based on serum albumin and total bilirubin levels.
Article Synopsis
- Prognostic stratification for colorectal cancer (CRC) patients is crucial, with the desmoplastic reaction (DR) potentially reflecting the tumor microenvironment and serving as a new prognostic indicator not previously included in existing nomograms.* -
- The study evaluated 329 CRC patients post-surgery to develop a new scoring system based on histopathological indicators such as tumor glandular differentiation, tumor budding, and lymph node metastasis.* -
- Findings indicated that the new D&M scoring system significantly improved predictions of disease-specific survival and recurrence-free survival compared to the current American Joint Committee on Cancer staging system, suggesting its potential as a valuable prognostic tool.*
Background: This study aimed to analyze the clinical outcomes after revascularization for chronic limb-threatening ischemia (CLTI) in patients aged ≥ 80 years and < 80 years.
Methods: We retrospectively analyzed multicenter data of 789 patients who underwent infrainguinal revascularization for CLTI between 2015 and 2021. The end points were 2-year overall survival (OS), amputation-free survival (AFS), limb salvage (LS), and postoperative complications.
Article Synopsis
- Immuno-oncology (IO) drugs are critical for cancer treatment, but older patients face safety issues, including higher hospitalization rates despite similar rates of immune-related adverse events (irAEs) compared to younger groups.* -
- A study analyzing clinical data from 181 patients over 80 years old found that 35% experienced irAEs, with 19% discontinuing therapy; elevated eosinophil counts were identified as a significant risk factor for developing these events.* -
- Overall, IO therapy is deemed safe for older patients, but those starting treatment with high eosinophil counts require careful monitoring.*
Article Synopsis
- - This study compared the effects of two treatment methods—bypass surgery and endovascular therapy (EVT)—on wound healing in patients with chronic limb-threatening ischemia (CLTI) who have varying conditions of the foot arteries (IM P0 and IM P1).
- - Results showed that bypass surgery led to significantly better wound healing and limb salvage rates in patients with severely diseased pedal arches (IM P1), while both methods had similar outcomes in patients with intact pedal arches (IM P0).
- - The findings suggest that bypass surgery is a more effective option for patients with tissue loss and IM P1 disease, but may not offer additional benefits over EVT for those with healthier foot arteries (IM P0).
Objective: This study aimed to evaluate treatment outcomes after bypass surgery or endovascular therapy (EVT) in average- and high-risk patients with chronic limb-threatening ischemia (CLTI).
Methods: We retrospectively analyzed multicenter data of patients who underwent infra-inguinal revascularization for CLTI between 2015 and 2022. A high-risk patient was defined as one with estimated 30-day mortality rate ≥5% or 2-year survival rate ≤50%, as determined by the Surgical Reconstruction vs Peripheral Intervention in Patients With Critical Limb Ischemia (SPINACH) calculator.
Background: Postoperative lymphatic leakage is a complication of ineffective conservative treatment for retroperitoneal mass. Herein, we report a case of lymphatic leakage that arose after retroperitoneal tumor resection and that was treated with retrograde transvenous thoracic duct embolization.
Case Presentation: A 28-year-old man with persistent abdominal pain was diagnosed with a large retroperitoneal metastatic tumor measuring 10 cm and a subdiaphragmatic lymph node originating from a testicular tumor.
Article Synopsis
- - The study focuses on a new method using a bioabsorbable polyglycolic acid spacer for safe carbon ion radiotherapy (CIRT) in treating locally recurrent rectal cancer near sensitive organs.
- - The laparoscopic technique was applied in five case studies, resulting in an average surgery time of 235 minutes with minimal blood loss (38 mL) and no pelvic infections.
- - Patients were able to start CIRT within two months post-surgery, and a video documenting the surgical procedure is referenced in the report.
An 80-year-old woman presented with epigastric discomfort and dysphagia, underwent upper gastrointestinal endoscopy, and was diagnosed with type 2 advanced lower esophageal adenocarcinoma. Computed tomography data revealed that there was the lower esophageal tumor is T3, but a large carina lymph node invading the left bronchus. We diagnosed this patient unresectable cT4bN1M0, cStage ⅣA advanced esophageal adenocarcinoma, and we administered nivolumab plus S-1 plus oxaliplatin(SOX)therapy.
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- A study assessed the impact of a daily elemental diet (ED) on skeletal muscle mass loss in gastric cancer patients after surgery, following previous findings that it reduced body weight loss postoperatively.
- The analysis utilized data from patients undergoing total or distal gastrectomy and compared changes in skeletal muscle mass index (%SMI) between those on the ED and control groups one year later.
- Results showed that while the ED group had a lower median %SMI loss than the control group, the difference was not statistically significant, indicating no clear benefit of the diet in preventing muscle loss post-gastrectomy.
Objective: This study aimed to evaluate three survival prediction models: the JAPAN Critical Limb Ischaemia Database (JCLIMB), Surgical Reconstruction Versus Peripheral Intervention in Patients With Critical Limb Ischaemia (SPINACH), and Vascular Quality Initiative (VQI) calculators.
Methods: Multicentre data of patients who underwent infrainguinal revascularisation for chronic limb threatening ischaemia between 2018 and 2021 were analysed retrospectively. The prediction models were validated using a calibration plot analysis with the intercept and slope.
Purpose: This study aimed to examine the incidence of incisional hernia (IH) in elective laparoscopic colorectal surgery (LC) using regulated computed tomography (CT) images at intervals every 6 months.
Methods: We retrospectively examined the diagnosis of IH in patients who underwent LC for colorectal cancer at Kansai Medical University Hospital from January 2014 to August 2018. The diagnosis of IH was defined as loss of continuity of the fascia in the axial CT images.
Objective: To examine limb salvage (LS) and wound healing in dialysis-dependent and -independent patients with chronic limb-threatening ischemia (CLTI) after infrainguinal bypass surgery or endovascular therapy (EVT).
Methods: We retrospectively analyzed the multi-center data of patients who underwent infrainguinal revascularization for CLTI with Wound, Ischemia, and foot Infection (WIfI) stage 2 to 4 between 2015 and 2020. The primary endpoint was LS.
Article Synopsis
- Adjuvant S-1 monotherapy is the standard post-surgery treatment for stage II gastric cancer in Japan, but its effectiveness for MSI-H tumors was previously unclear.
- A study analyzed 184 out of 208 stage II gastric cancer patients treated with S-1 after surgery, finding that 13% had microsatellite instability-high (MSI-H) tumors.
- While survival rates didn't significantly differ, MSI-H patients showed slightly better relapse-free and overall survival rates, suggesting different recurrence mechanisms between MSI-H and microsatellite-stable (MSS) tumors.
The CARMA1-Bcl10-MALT1 (CBM) signalosome is a crucial module of NF-κB activation in B cell receptor (BCR) signaling. Biophysical studies have shown that the E3 ubiquitin ligase TRAF6 cooperatively modifies the CBM signalosome; however, the specific details regarding how TRAF6 is involved in BCR signal-induced CBM formation remain unclear. In this study, we aimed to reveal the influences of TRAF6 on CBM formation and TAK1 and IKK activities using DT40 B cells which lack all the exons of TRAF6.
View Article and Find Full Text PDFBackground: Patients with smoldering ATLL often present with a skin eruption due to skin infiltration of ATLL cells. Although skin eruption type is known to be associated with prognosis based on its pattern, it is unknown why different types of skin eruptions are associated with different prognoses.
Objective: Genomic analysis of patients with skin eruptions of smoldering ATLL will be performed to determine the mechanism of ATLL development and its association with prognosis.
Purpose: This study investigated the associations of personality traits and preoperative lifestyle improvements with early weight loss after sleeve gastrectomy.
Methods: This was a single-center, retrospective study of 57 patients who underwent preoperative lifestyle intervention with a multidisciplinary team approach based on cognitive behavioral therapy before sleeve gastrectomy. All patients underwent preoperative psychological testing with the Neuroticism-Extraversion-Openness Five-Factor Inventory (NEO-FFI) and the Tokyo University Egogram New Version II (TEG II).
Osteopetrosis is a heterogeneous group of heritable conditions. It varies greatly in severity, and fracture treatment remains a matter of controversy due to altered responses to fixation and the risk of osteomyelitis. Therefore, sternotomy outcomes in this condition are unclear.
View Article and Find Full Text PDFA 46-year-old woman was referred for hypertension and a right adrenal tumor. Primary aldosteronism (PA) was suspected because of the high plasma aldosterone concentration-to-plasma renin activity ratio. However, a subsequent evaluation revealed coexistent PA and pheochromocytoma.
View Article and Find Full Text PDFBackground: Surgical resection of oligo-metastasis in gastric cancer (GC) is weakly recommended for patients without other incurable factors in the Japanese GC Treatment Guidelines. While post-operative chemotherapy is the standard treatment in patients with stage II or III GC, its efficacy for resected stage IV GC is unclear. This study aimed to evaluate the efficacy of post-operative chemotherapy after curative resection of GC with oligo-metastasis.
View Article and Find Full Text PDFBackground And Aim: The risk of hepatocellular carcinoma (HCC) persists in a condition of sustained virologic response (SVR) after hepatitis C virus (HCV) eradication. Comprehensive molecular analyses were performed to test the hypothesis that epigenetic abnormalities present after an SVR play a role in hepatocarcinogenesis.
Methods: Whole-genome methylome and RNA sequencing were performed on HCV, SVR, and healthy liver tissue.
Background: Late complications following gastric cancer surgery, including postgastrectomy syndromes, are complex problems requiring a solution. Reported risk factors for developing late complications include surgery-related factors, such as the surgical approach and the extent of resection and reconstruction. However, this has not been assessed in a prospective study with a large sample size.
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