Publications by authors named "Kentaro Hirayama"
Background: Elevated albumin-free or unbound bilirubin (UB) levels beyond the first week of life have been associated with the development of bilirubin encephalopathy in preterm infants. However, the mechanism(s) that induces this prolonged unbound bilirubinemia has remained unknown. We hypothesized that it may due to a sustained lower bilirubin-binding affinity of albumin in extremely premature infants.
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- The study investigates a new fixed-time protocol for measuring unbound bilirubin (UB) levels in newborns, as an alternative to the more time-consuming original glucose oxidase-peroxidase (GOD-POD) method.
- Researchers hypothesized that measuring total bilirubin (TB) decrease over set time intervals could accurately estimate UB levels.
- Results showed that the fixed-time protocol, particularly in 20-40 second intervals, correlated strongly with the original method and offered high precision in measurement.
The effects of medical and surgical interventions on the survival of patients with trisomy 18 have been reported, leading to changes in perinatal management and decision-making. However, few studies have fully reported the recent changes in survival and treatment of trisomy 18. We examined how treatment and survival of patients with trisomy 18 have changed over a decade in a Japanese pediatric tertiary referral center.
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- The research focuses on the presence of sugar nucleotides, specifically UDP oligosaccharides, in the milk and colostrum of certain mammals, which have not been fully characterized until now.
- The study successfully isolated two specific UDP-sialyl N-acetyllactosamines from sheep colostrum and analyzed their structures using advanced spectroscopic techniques like (1)H-NMR and MALDI-TOFMS.
- The identified structures of these oligosaccharides are Neu5Gc(α2-3)Gal(β1-4)GlcNAcα1-UDP and Neu5Gc(α2-6)Gal(β1-4
Article Synopsis
- - The study focused on isolating milk oligosaccharides from tiger quoll milk, a marsupial related to the eastern quoll, and characterized them using advanced techniques like NMR spectroscopy and mass spectrometry.
- - A variety of oligosaccharides were identified, including different complex sugar structures with specific linkages involving galactose (Gal), glucose (Glc), and N-acetylglucosamine (GlcNAc).
- - Larger oligosaccharide structures with multiple sugar units and specific linkages were also characterized, indicating the complexity and diversity of oligosaccharides in tiger quoll milk.
Previous structural characterizations of marsupial milk oligosaccharides have been performed in the tammar wallaby, red kangaroo, koala, common brushtail possum and the eastern quoll. To clarify the homology and heterogeneity of milk oligosaccharides among marsupial species, which could provide information on their evolution, the oligosaccharides of wombat milk carbohydrate were characterized in this study. Neutral and acidic oligosaccharides were isolated from the carbohydrate fractions of two samples of milk of the common wombat and characterized by (1) H-nuclear magnetic resonance spectroscopy.
View Article and Find Full Text PDFStructural characterizations of marsupial milk oligosaccharides have been performed in four species to date: the tammar wallaby (Macropus eugenii), the red kangaroo (Macropus rufus), the koala (Phascolarctos cinereus) and the common brushtail possum (Trichosurus vulpecula). To clarify the homology and heterogeneity of milk oligosaccharides among marsupials, the oligosaccharides in the carbohydrate fraction of eastern quoll milk were characterized in this study. Neutral and acidic oligosaccharides were separated and characterized by (1)H-nuclear magnetic resonance spectroscopy and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
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