Publications by authors named "Kenta Yoshii"
Background: The rising number of patients with dementia has become a serious social problem worldwide. To help detect dementia at an early stage, many studies have been conducted to detect signs of cognitive decline by prosodic and acoustic features. However, many of these methods are not suitable for everyday use as they focus on cognitive function or conversational speech during the examinations.
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- The study focused on delivering chlorogenic acid, a hydrophilic polyphenol, through the skin using excised guinea pig and Yucatan micropig skin models.
- Chlorogenic acid showed better skin accumulation and solubility in aqueous solutions compared to other polyphenols like quercetin and genistein, but needed enhanced delivery for effective protection against oxidative skin damage.
- Using an oil-in-water (o/w-type) microemulsion as a vehicle significantly improved the skin absorption of chlorogenic acid, and pretreatment with this microemulsion gel reduced UV-induced skin damage.