Publications by authors named "Kenta Asao"
Article Synopsis
- MraY inhibitory natural products are promising candidates for new antibacterial treatments, especially against drug-resistant bacteria, but improving their properties through chemical modifications is challenging due to complex synthesis processes.
- A new strategy has been developed to efficiently create and evaluate a library of 686 MraY analogue compounds, allowing for streamlined preparation and direct assessment of their biological activities.
- This research identifies several potent analogues that are effective against drug-resistant strains and reveals unique binding patterns with MraY, while also demonstrating the method's applicability to other natural products targeting tubulin activities.
