Effect of spironolactone on vascular stiffness in hemodialysis patients: a randomized crossover trial.

Background: The role of spironolactone treatment in hemodialysis patients is debated, but a survival benefit is suggested. Mineralocorticoids and chronic kidney disease have been linked to cardiovascular fibrosis. Therefore, we hypothesized that spironolactone would affect vascular stiffness, cardiac systolic, and diastolic function in hemodialysis patients.

[Platypnea-orthodeoxia syndrome: a neglected cause of dyspnea?].

A 68-year-old woman presented with progressive and severe effort-related dyspnea. Her history included an ischemic stroke at age 43. Routine exams were normal.

Characteristics and survival of adult Swedish PAH and CTEPH patients 2000-2014.

Objectives: The Swedish Pulmonary Arterial Hypertension Register (SPAHR) is an open continuous register, including pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) patients from 2000 and onwards. We hereby launch the first data from SPAHR, defining baseline characteristics and survival of Swedish PAH and CTEPH patients.

Design: Incident PAH and CTEPH patients 2008-2014 from all seven Swedish PAH-centres were specifically reviewed.

Thirty-year electrocardiographic follow-up after repair of tetralogy of Fallot or atrial septal defect.

Background And Purpose: Knowledge about long-term electrocardiographic changes after surgery for congenital heart disease is limited.

Methods: Eleven patients with corrected tetralogy of Fallot (ToF) and 14 with corrected atrial septal defect (ASD) were followed up at 20 and 30 years after surgery.

Results: Approximately 50% of the ASD group developed prolonged QRS duration.